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首页> 外文期刊>Journal of Medical Sciences >Comparative Study of the in vivo Response of Malaria Parasites to Chloroquine among the Urban and Rural Dwellers in Sokoto State, Nigeria
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Comparative Study of the in vivo Response of Malaria Parasites to Chloroquine among the Urban and Rural Dwellers in Sokoto State, Nigeria

机译：尼日利亚索科托州城乡居民中疟原虫对氯喹体内反应的比较研究

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The in vivo response of malaria parasites to chloroquine among the urban and rural dwellers in Sokoto state, Nigeria has been studied. A total of seventy-eight patients with acute uncomplicated malaria were selected for the study from two distinct centres representing the urban and rural dwellers of the state. All the treated cases from the rural centre (Umaruma) responded well; both the clinical features of the disease and the parasites in the blood cleared within three days of initiating treatment and there was no relapse after twenty-one days follow up. But 19.8% (5) of the patients from the urban centre showed resistance at R1 level to chloroquine. This study therefore concluded that, chloroquine is more effective for the treatment of malaria in the rural than the urban dwellers possibly because of the rampant abuse of the drug by the later group.
机译：研究了尼日利亚索科托州城乡居民中疟原虫对氯喹的体内反应。从代表该州城市和农村居民的两个不同中心选择了总共78例急性单纯性疟疾患者进行研究。来自农村中心（Umaruma）的所有治疗病例反应良好。在开始治疗的三天内，该疾病的临床特征和血液中的寄生虫均被清除，并且在随访二十一天后没有复发。但是，来自市中心的患者中有19.8％（5）的患者对氯喹的耐药性处于R1水平。因此，这项研究得出的结论是，氯喹对农村地区的疟疾比城市居民更有效的疟疾治疗，可能是因为后者对该群体的滥用猖ramp。

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