首页> 外文期刊>Journal of Medical Sciences >Evaluation of Lesion Scoring and Aniline Hydroxylase Activity in Hepatocarcinogenesis Rats Treated with Strobilanthes crispus
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Evaluation of Lesion Scoring and Aniline Hydroxylase Activity in Hepatocarcinogenesis Rats Treated with Strobilanthes crispus

机译:雷公藤多孢菌治疗肝癌大鼠病变评分和苯胺羟化酶活性的评价

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The effect of 5% w/v of Strobilanthes crispus (SC) extract and glycyrrhizin in diethylnitrosamine and acetylaminofluorene induced hepatocellular carcinoma, which is a vital mechanism in cancer treatment, was studied in male Sprague-Dawley rats. The obtained results have shown a significant, increase (p caused overall decrease in liver AH activity almost near to control groups. Meanwhile, microscopic observation of the lesion score during hepatocarcinogenesis revealed that cells of cancer group without treatment were severely necrotic at week 12. However, S. crispus treatment was reduced the severity in cancer group rats at week 12. The result also indicate that SC only ameliorated the cancer incidence in the liver, however did not fully recover the liver tumor similar to the normal cells. This might be due to short experimental duration.
机译:在雄性Sprague-Dawley大鼠中研究了5%w / v的Strobilanthes crispus(SC)提取物和甘草甜素在二乙基亚硝胺和乙酰氨基芴诱发的肝细胞癌中的作用,这是癌症治疗的重要机制。获得的结果显示出显着的增加(p导致几乎在对照组附近的肝脏AH活性总体下降。),在肝癌发生过程中显微镜观察病变评分,发现未经治疗的癌细胞组在第12周严重坏死。 ,S. crispus治疗在第12周时降低了癌症组大鼠的严重程度,结果还表明SC仅改善了肝脏中的癌症发生率,但没有像正常细胞那样完全恢复肝肿瘤,这可能是由于缩短实验时间。

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