• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Medical Sciences >Clotting Factors in Patients with Acute and Chronic Gout
【24h】

Clotting Factors in Patients with Acute and Chronic Gout

机译：急性和慢性痛风患者的凝血因子

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Since clotting factor abnormalities could contribute to the raised cardiovascular risk profile of patients with gout, this project was to assess possible changes in Factor VII and VIII. Levels of fibrinogen and of clotting Factor VII and VIII were measured in patients with clinical gout, both acute and chronic (intercritical) and were compared with those in healthy controls, closely matched for age and sex. Median levels of fibrinogen were significantly higher in patients with acute gout than in patients with intercritical gout (p = 0.02) or controls (p = 0.005). In view of the already raised thrombotic risk profile in gout patients as a group, it is reassuring that hyperfibrinogenaemia only seems to be present during acute attacks of gout, presumably as an acute phase response. It is unlikely, therefore, that the hyperfibrinogenaemia noted during acute attacks of gout contributes significantly to the chronically raised cardiovascular risk profile of long-term gout patients.
机译：由于凝血因子异常可能导致痛风患者的心血管风险升高，因此该项目旨在评估凝血因子VII和VIII的可能变化。在患有临床痛风的急性和慢性（间质性）患者中测量纤维蛋白原水平以及凝血因子VII和VIII的水平，并与年龄和性别均相匹配的健康对照者进行比较。急性痛风患者的纤维蛋白原水平中位数显着高于临界痛风患者（p = 0.02）或对照组（p = 0.005）。鉴于痛风患者的血栓风险已经增加，可以放心的是，高纤维蛋白原性血症似乎仅在痛风的急性发作期间出现，大概是急性阶段反应。因此，在痛风急性发作期间注意到的高纤维蛋白原性贫血不太可能对长期痛风患者的慢性心血管风险特征有明显贡献。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号