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首页> 外文期刊>Journal of Medical Sciences >Impact of Parathormone Hormone on Platelet Count and Mean Volume in End-stage Renal Failure Patients on Regular Hemodialysis
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Impact of Parathormone Hormone on Platelet Count and Mean Volume in End-stage Renal Failure Patients on Regular Hemodialysis

机译：定期血液透析对副激素对终末期肾衰竭患者血小板计数和平均体积的影响

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The increased bleeding tendency of end-stage renal failure patients under hemodialysis (HD) has been attributed to platelet dysfunction. We sought to conduct a study to consider the effect of parathormone on mean platelet volume and count in chronic hemodialysis patients. Complete blood count containing platelet count and Mean Platelet Volume (MPV) and levels of serum calcium, phosphorus, alkaline phosphatase and Intact serum PTH (iPTH) were measured. Total patients were 36 (F = 14, m = 22), consisting of 26 non-diabetic HD patients and 10 diabetic HD patients. Findings were a near significant difference of PLT count between diabetic and non-diabetic HD patients with more values in diabetic population, a significant inverse correlation PLT count and MPV and a near significant positive correlation of MPV with serum iPTH. A significant inverse correlation of PLT count with serum iPTH was seen too. The inverse correlation of serum parathormone with platelet count and the positive correlation of serum parathormone with MPV shows the role of secondary hyperparathyroidism in PLT dysfunction regarding the bleeding tendency of uremic patients, which implies to better control of PTH over secretion in these patients.
机译：血液透析（HD）下终末期肾衰竭患者出血趋势的增加归因于血小板功能障碍。我们试图进行一项研究，以考虑副激素对慢性血液透析患者的平均血小板体积和计数的影响。测量了包括血小板计数和平均血小板体积（MPV）的全血细胞计数以及血清钙，磷，碱性磷酸酶和完整血清PTH（iPTH）的水平。总患者为36（F = 14，m = 22），由26位非糖尿病HD患者和10位糖尿病HD患者组成。结果发现，糖尿病和非糖尿病HD患者之间的PLT计数存在显着差异，糖尿病人群中PLT计数更高，PLT计数与MPV呈显着负相关，MPV与血清iPTH呈显着正相关。还发现PLT计数与血清iPTH呈显着负相关。血清甲状旁腺素与血小板计数呈负相关，血清甲状旁腺素与MPV呈正相关，说明继发性甲状旁腺功能亢进在PLT功能障碍中与尿毒症患者的出血趋势有关，这意味着可以更好地控制这些患者的PTH分泌。

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