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首页> 外文期刊>Journal of Medicinal Plants Research >Antimicrobial, antioxidant and in vitro anti-inflammatory activity and phytochemical screening of water extract of Wedelia trilobata (L.) Hitchc.
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Antimicrobial, antioxidant and in vitro anti-inflammatory activity and phytochemical screening of water extract of Wedelia trilobata (L.) Hitchc.

机译：Wedelia trilobata（L.）Hitchc水提取物的抗菌，抗氧化剂和体外抗炎活性以及植物化学筛选。

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The aim of the study was to evaluate antimicrobial, antioxidant and anti-inflammatory activity of dry and fresh parts of leaf, stem and flower from the water extract of Wedelia trilobata. The antimicrobial activity of water extracts of fresh and dry parts against 9 different strains of bacteria and 11 different species of fungi were determined using standard method (paper disc method).?The fresh parts water extracts showed that, leaf and flower extracts were most potent inhibiting all isolates of with different zones of inhibition but did not inhibited the growth of fungi tested. All the extracts have only moderately inhibited the all fungi. The minimum microbial concentration (MMC) of the active extract was observed from fresh part extracts of leaf, flower and stem ranged from 0.4 to 5.0 mg/ml for the sensitive bacteria. In case of fungi, the minimum inhibitory concentration (MIC) of the active extracts ranged from 2.4 to 6.0 mg/ml. Together, these data suggest that the W. trilobata fresh parts extracts analyzed are potential antimicrobial candidates with a broad range of activity. Phytochemical screening of extracts showed the presence of tannins, cardiac glycosides, flavonoids, terpenoids, phenols, saponins and coumarins. Leaf and flower water have showed highest total phenolic content. In?2, 2-diphenyl-1-picrylhydrazyl (DPPH) and?ferric ion reducing antioxidant power (FRAP) method, the leaf and flower had showed free radical inhibition of 86, 83 and?1623.21,?1611.26,?respectively and they also showed in vitro anti-inflammatory activity by inhibiting the heat induced albumin denaturation and red blood cells membrane stabilization with 89.61 and 86.81 and 78.82, 76.65 g/ml, respectively. Proteinase activity was also significantly inhibited by the leaf (83.91 g/ml) and flower (81.17 g/ml). From the result, it is concluded that phytochemicals present in the W. trilobata extract may be responsible and can be used as antimicrobial, antioxidant and anti-inflammatory agent.
机译：该研究的目的是评估从Wedelia trilobata的水提取物中得到的叶，茎和花的干燥和新鲜部分的抗菌，抗氧化和抗炎活性。采用标准方法（纸盘法）测定了新鲜和干燥部分水提取物对9种不同细菌和11种真菌的抗菌活性。新鲜部分水提取物显示，叶和花提取物最有效抑制所有分离株具有不同的抑制区域，但没有抑制所测试真菌的生长。所有的提取物仅中等抑制所有真菌。从敏感细菌的叶，花和茎的新鲜部分提取物中观察到活性提取物的最低微生物浓度（MMC）为0.4至5.0 mg / ml。如果是真菌，活性提取物的最小抑菌浓度（MIC）为2.4至6.0 mg / ml。总之，这些数据表明，分析的三叶W.新鲜部分提取物是具有广泛活性的潜在抗微生物候选物。提取物的植物化学筛选显示单宁，强心苷，类黄酮，萜类，酚，皂苷和香豆素的存在。叶和花水显示出最高的总酚含量。在？2、2-二苯基-1-吡咯肼基（DPPH）和？铁离子还原抗氧化能力（FRAP）方法中，叶和花分别显示了86、83和？1623.21，？1611.26？的自由基抑制作用，并且它们分别还通过分别以89.61和86.81和78.82、76.65 g / ml抑制热诱导的白蛋白变性和红细胞膜稳定来显示体外抗炎活性。叶片（83.91 g / ml）和花朵（81.17 g / ml）也显着抑制蛋白酶活性。从结果可以得出结论，W。trilobata提取物中存在的植物化学物质可能是负责任的，并且可以用作抗微生物剂，抗氧化剂和抗炎剂。

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