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首页> 外文期刊>Journal of Medicinal Plants Research >Antioxidant and anti-glycated activities of polysaccharides in vitro isolated from Hedyotis diffusa Willd.
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Antioxidant and anti-glycated activities of polysaccharides in vitro isolated from Hedyotis diffusa Willd.

机译：白花蛇舌草体外分离多糖的抗氧化和抗糖化活性。

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摘要

The extraction and isolation of four crude polysaccharides from?Hedyotis diffusa?Willd., as well as the evaluation of their antioxidant and anti-glycated activities?in vitro?were investigated. The whole plant of?H. diffusa?was extracted with hot distilled water and three fractions of crude polysaccharides, termed as 50P, 70P and 90P were obtained by graded ethanol precipitation, BP were gained by NaOH solution extracted followed by ethanol precipitation. All of the four polysaccharides were defatted with petroleum ether and protein was removed? by the Sevag reagent. Preliminary antioxidant?in vitro?indicated that the four crude polysaccharides showed powerful and dose-dependent scavenging abilities on DPPH· and hydroxyl radicals. For the first time, the anti-glycated activities of the four samples were studied, and they had good potential in inhibiting the non-enzymatic glycation reaction with dose-dependent effects. In particular, 90P showed even better antioxidant and anti-glycated activities than corresponding positive control. Therefore,?H. diffusa?crude polysaccharides have potential value on the prevention and treatment of some diseases caused by oxidant and aging, and worthy of further research and development.
机译：研究了白花蛇舌草（Hedyotis diffusa）中四种粗多糖的提取，分离及其体外抗氧化和抗糖化活性的评价。 H的整个植物。用热蒸馏水提取白花蛇舌草，分级乙醇沉淀法得到三部分粗多糖，分别为50P，70P和90P，NaOH提取液再经乙醇沉淀得到BP。所有四种多糖均已用石油醚脱脂，并且去除了蛋白质？通过塞瓦格试剂。初步抗氧化剂“体外”表明，这四种粗多糖对DPPH·和羟基自由基具有强大的剂量依赖性清除能力。首次对这四个样品的抗糖化活性进行了研究，它们在抑制非酶糖基化反应方面具有良好的潜力，且具有剂量依赖性。特别是90P的抗氧化剂和抗糖化活性比相应的阳性对照更好。因此，？白花蛇舌草多糖在预防和治疗由氧化剂和老化引起的某些疾病方面具有潜在价值，值得进一步研究和开发。

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