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首页> 外文会议>Proceedings of the 6th CCTCNM-KSP-JSP joint symposium on pharmacognosy >In vitro antioxidant activities of polysaccharide from Hedyotis diffusa Willd.
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In vitro antioxidant activities of polysaccharide from Hedyotis diffusa Willd.

机译：白花蛇舌草多糖的体外抗氧化活性。

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摘要

It is well known that polysaccharides play an important role in the growth and development of living organisms. In recent years, more and more polysaccharides have been reported to exhibit a variety of biological activities, such as antioxidant, anti-inflammatory, antitumour, antimutagenic, antiglycation, immunomodulatory, etc. Some botanical polysaccharides have been commercially developed into important components of therapeutic drugs and skin care products. The present paper studies the extraction and isolation of four crude polysaccharides from Hedyotis diffusa Willd, as well as the evaluation of their antioxidant activity in vitro. The whole plant of H. diffusa was treated with petroleum ether to remove lipid and pigment. Then, defatted meals were extracted with hot distilled water, and the combined aqueous extracts were filtered, concentrated and removed protein by the Sevag reagent. Three fractions of crude polysaccharides, termed as HD50, HD70 and HD90 were obtained by graded ethanol precipitation, HDB were gained by NaOH solution extracted followed by ethanol precipitation. Through antioxidant assay in vitro, the four crude polysaccharides showed powerful and dose-dependent scavenging abilities on DPPH and Hydroxyl radicals. Therefore, the crude polysaccharide from H. diffusa should be explored as a novel potential antioxidant. Therefore, H. diffusa crude polysaccharides have potential value on the prevention and treatment of some diseases caused by oxidant and aging, and worthy of further research and development.
机译：众所周知，多糖在活生物体的生长和发育中起着重要作用。近年来，越来越多的多糖具有多种生物活性，例如抗氧化剂，抗炎剂，抗肿瘤剂，抗诱变剂，抗糖基化剂，免疫调节剂等。据报道，某些植物性多糖已被商业化开发为治疗药物的重要组成部分。和皮肤护理产品。本文研究了白花蛇舌草中四种粗多糖的提取，分离及其体外抗氧化活性的评价。用石油醚处理白花蛇舌草全株以去除脂质和色素。然后，用热蒸馏水提取脱脂粗粉，并过滤合并的水提取液，浓缩并通过Sevag试剂去除蛋白质。通过分级乙醇沉淀获得三部分粗多糖，分别为HD50，HD70和HD90，通过NaOH溶液萃取然后乙醇沉淀获得HDB。通过体外抗氧化剂测定，这四种粗多糖对DPPH和羟自由基显示出强大的剂量依赖性清除能力。因此，应将白花蛇舌草的粗多糖作为一种潜在的新型抗氧化剂进行研究。因此，白花蛇舌草粗多糖在预防和治疗由氧化剂和老化引起的某些疾病方面具有潜在价值，值得进一步研究和开发。

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