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首页> 外文期刊>Journal of nanomaterials >In VitroBiocompatibility of Endodontic Sealers Incorporating Antibacterial Nanoparticles
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In VitroBiocompatibility of Endodontic Sealers Incorporating Antibacterial Nanoparticles

机译：结合抗菌纳米颗粒的牙髓封闭剂的体外生物相容性

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The main cause of endodontic disease is bacteria. Disinfection is presently achieved by cleaning the root canal system prior to obturation. Following setting, root canal filling is devoid of any antibacterial effect. Endodontic sealers with antimicrobial properties yet biocompatible may enhance root canal therapy. For this purpose, quaternized polyethylenimine nanoparticles which are antibacterial polymers, biocompatible, nonvolatile, and stable may be used. The aim of the present study was to examine the impact of added QPEI on the cytotoxicity of AH Plus, Epiphany, and GuttaFlow endodontic sealers. The effect of these sealers on the proliferation of RAW 264.7 macrophage and L-929 fibroblast cell lines and on the production of TNFαfrom macrophages was examined. Cell vitality was evaluated using a colorimetric XTT assay. The presence of cytokines was determined by two-site ELISA. Results show that QPEI at 1% concentration does not impair the basic properties of the examined sealers in both macrophages and fibroblast cell lines. Incorporation of 1% QPEI into the sealers did not impair their biocompatibility. QPEI is a potential clinical candidate to improve antibacterial activity of sealers without increasing cytotoxicity.
机译：牙髓疾病的主要原因是细菌。目前，通过在阻塞之前清洁根管系统来实现消毒。凝固后，根管填充没有任何抗菌作用。具有抗菌特性但具有生物相容性的牙髓封闭剂可增强根管治疗。为此，可以使用季铵化的聚乙烯亚胺纳米颗粒，其是抗菌聚合物，生物相容性，非挥发性的和稳定的。本研究的目的是研究添加QPEI对AH Plus，Epiphany和GuttaFlow牙髓封闭剂的细胞毒性的影响。检查了这些封闭剂对RAW 264.7巨噬细胞和L-929成纤维细胞系增殖以及巨噬细胞产生TNFα的影响。使用比色XTT测定法评估细胞活力。通过两点ELISA确定细胞因子的存在。结果表明，浓度为1％的QPEI不会损害巨噬细胞和成纤维细胞系中所研究的封闭剂的基本特性。将1％QPEI加入密封剂中不会损害其生物相容性。 QPEI是提高封闭剂抗菌活性而不增加细胞毒性的潜在临床候选者。

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