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首页> 外文期刊>Journal of Molecular Biochemistry >Selective lactase deficiency is common in pediatric patients undergoing upper endoscopy
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Selective lactase deficiency is common in pediatric patients undergoing upper endoscopy

机译：选择性乳糖酶缺乏症在接受上内镜检查的儿科患者中很常见

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Lactase deficiency can lead to significant symptoms in the pediatric population. To date, few studies have examined the prevalence of enzyme testing-based lactase and other disaccharidase deficiencies (DDs) in pediatric patients undergoing upper endoscopic evaluation. The primary objective of this study was to determine the prevalence of selective lactase and other DDs amongst a large cohort of pediatric patients with and without inflammatory bowel disease (IBD: Crohn’s disease and ulcerative colitis) via a chart review of 739 patients who underwent esophago-gastro-dudenoscopy EGD between April 2010 and August 2016. We identified 560 pediatric patients (ages 1-18 years) who underwent mucosal enzyme testing at the time of their EGD. The overall rate of lactase deficiency (LD) was 39%. LD positively correlated with age (p=0.00017), but there was no significant difference between age matched IBD and non-IBD patients (45% vs. 42% p=0.68). Four patients (0.17%) were found to have selective maltase deficiency. No selective sucrase or palatinase deficiency was identified. Statistically significant differences occurred in lactase deficiency amongst patients of different races. In conclusion, lactase deficiency is a relatively common finding in children undergoing EGD though at no increased rate amongst the IBD patient population. Disaccharidase testing should be considered in pediatric patients undergoing EGD.
机译：乳糖酶缺乏症可导致小儿症状严重。迄今为止，很少有研究检查接受内镜评估的儿科患者中基于酶检测的乳糖酶和其他双糖酶缺乏症（DDs）的患病率。这项研究的主要目的是通过对739例接受食管癌治疗的患者进行图表回顾，确定大批有和没有炎性肠病（IBD：克罗恩病和溃疡性结肠炎）的小儿患者中选择性乳糖酶和其他DD的患病率。在2010年4月至2016年8月期间进行胃十二指肠镜EGD。我们确定了560例EGD时接受过粘膜酶检测的儿科患者（年龄1-18岁）。乳糖酶缺乏症（LD）的总发生率为39％。 LD与年龄呈正相关（p = 0.00017），但年龄相匹配的IBD和非IBD患者之间无显着差异（45％vs. 42％p = 0.68）。发现四名患者（0.17％）患有选择性麦芽糖酶缺乏症。没有发现选择性蔗糖酶或帕拉金酶缺乏症。在不同种族的患者中，乳糖酶缺乏症发生统计学差异。总之，乳糖酶缺乏症在接受EGD的儿童中是相对普遍的发现，尽管在IBD患者人群中没有增加。在接受EGD的小儿患者中，应考虑使用双糖酶检测。

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