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首页> 外文期刊>Journal of Molecular Biochemistry >How complex an intron may be? The example of the first intron of the CTP synthase gene of Drosophila melanogaster
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How complex an intron may be? The example of the first intron of the CTP synthase gene of Drosophila melanogaster

机译：内含子可能有多复杂？果蝇CTP合酶基因第一个内含子的例子。

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In eukaryotes, maturation of primary transcripts into mature messenger RNAs involves the elimination of parts of the gene called ‘introns’. The biological significance of introns is not yet completely understood. It has been demonstrated that introns may contain other genes, or regulatory sequences that may be involved in transcriptional control, or also being involved in alternative splicing mechanisms. However, these functions explain the role of only a small number of them, and it is very difficult to formulate any generalization. The CTP synthase gene of Drosophila melanogaster is characterized by the presence of a long first intron (approximately 7.2 kilobases) whose role is currently unknown. In the present report we analyzed in silico the content of this intron, and found that it contains at least three interesting sub-sequences. Two of them are homologous to the CTP synthase itself and to a putative nucleotide pyrophosphatase, respectively. The third is a short stretch of DNA able to fold into a thermodynamically stable hairpin and showing homology with other 19 sequences from 21 genes inside the D. melanogaster genome. These findings suggest a complex yet very accurate way of controlling gene expression inside the fruit fly.
机译：在真核生物中，初级转录本成熟为成熟的信使RNA的过程涉及消除称为“内含子”的基因部分。内含子的生物学意义尚未完全理解。已经证明内含子可能含有其他基因，或可能参与转录控制或也参与其他剪接机制的调控序列。但是，这些功能仅解释了其中少数的作用，并且很难表述任何概括。果蝇的CTP合酶基因的特征是存在一个长的内含子（约7.2 kb），其作用目前尚不清楚。在本报告中，我们通过计算机分析了该内含子的含量，发现该内含子至少包含三个有趣的子序列。它们中的两个分别与CTP合酶本身和推定的核苷酸焦磷酸酶同源。第三个是一小段DNA，能够折叠成热力学稳定的发夹，并与黑腹果蝇D. melanogaster基因组中21个基因的其他19个序列具有同源性。这些发现提示了控制果蝇内部基因表达的复杂但非常准确的方法。

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