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首页> 外文期刊>Journal of Molecular Biochemistry >Genome sequences of triacylglycerol metabolism in Rhodococcus as a platform for comparative genomics
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Genome sequences of triacylglycerol metabolism in Rhodococcus as a platform for comparative genomics

机译：红球菌中三酰基甘油代谢的基因组序列作为比较基因组学的平台

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Bacteria belonging to the Rhodococcus genus are usually able to synthesize and accumulate variable amounts of triacylglycerols (TAG) from diverse carbon sources. Although some significant advances in the basic knowledge on TAG metabolism in rhodococci have been made, the fundamental understanding of this process and its regulation remains to be clarified. The abundantly available genomic information for several rhodococcal species provides the possibility for comparative genome analysis on the occurrence and distribution of key genes and pathways involved in TAG metabolism. Our bioinformatic analyses of available databases from six rhodococcal strains demonstrated that genes/enzymes for reactions related to TAG biosynthesis and degradation, and fatty acid β-oxidation are surprisingly abundant in rhodococcal genomes. Several genes/enzymes of glycerolipids and fatty acid metabolism are highly represented in the analyzed genomes. A number of previously undescribed, new putative genes for glycerolipid metabolism in rhodococci have been identified and the size of each family has been estimated.
机译：属于红球菌属的细菌通常能够合成和积累来自多种碳源的可变量的三酰甘油（TAG）。尽管在红球菌中TAG代谢的基础知识方面已取得了一些重大进展，但对这一过程及其调控的基本理解仍有待澄清。几种红球菌物种的丰富可用的基因组信息为比较基因组分析提供了可能，这些基因组分析涉及TAG代谢的关键基因和途径的发生和分布。我们对来自六个红球菌菌株的可用数据库的生物信息学分析表明，在红球菌基因组中，与TAG生物合成和降解以及脂肪酸β-氧化有关的反应的基因/酶令人惊讶。甘油脂和脂肪酸代谢的几种基因/酶在分析的基因组中高度代表。已经确定了许多以前未描述的杜鹃球菌甘油脂代谢的新推定基因，并已估计了每个家族的大小。

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