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Antimicrobial activities of caffeic acid phenethyl ester

机译：咖啡酸苯乙酯的抗菌活性

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Caffeic acid phenethyl ester (CAPE) is considered as one of the most active components of Propolis extract (PE), a natural product obtained from beehives. PE comprises a complex of chemicals and has been found to have various biological activities. The aim of the present study is to assess the antibacterial activities CAPE has against various gram positive [gram (+)] and gram negative [gram (-)] bacteria and try to elucidate its mechanism of action. Bacteria were grown in the presence of various doses of CAPE and examined at different periods of time for their growth, both by absorbance (OD) measurement and colony assay. The results show that CAPE significantly inhibited the growth of most examined gram (+) bacteria while having only a slight inhibitory effect on most tested gram (-) bacteria. Our results also show that continuous treatment of gram (+) bacteria with CAPE for at least 6h caused irreversible inhibition of the bacterial growth (bacteriocidic effect); however, treatment for shorter periods of time caused only a stopping of bacterial growth (bacteriostatic effect). It seems that these effects were caused, at least partially, as a result of disruptions of the treated bacterial outer and plasma membranes. There is no significant synergistic effect between CAPE and ampicillin, although an additive effect has been found.
机译：咖啡酸苯乙酯（CAPE）被认为是蜂胶提取物（PE）的最有效成分之一，蜂胶提取物是从蜂箱中提取的天然产物。 PE由多种化学物质组成，具有多种生物活性。本研究的目的是评估CAPE对各种革兰氏阳性[gram（+）]和革兰氏阴性[gram（-）]细菌的抗菌活性，并试图阐明其作用机理。细菌在各种剂量的CAPE存在下生长，并在不同时间段通过吸光度（OD）测量和菌落测定检查其生长。结果表明，CAPE显着抑制了大多数被检查的革兰氏细菌的生长，而对大多数被测试的革兰氏细菌只有轻微的抑制作用。我们的结果还表明，用CAPE连续处理革兰氏（+）细菌至少6h会导致不可逆地抑制细菌生长（杀菌作用）。然而，较短时间的治疗仅引起细菌生长的停止（抑菌作用）。这些作用似乎至少部分是由于处理过的细菌外膜和质膜的破坏引起的。尽管发现了加和作用，但CAPE和氨苄西林之间没有明显的协同作用。

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