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首页> 外文期刊>Journal of neuroinflammation >Vitamin D mitigates age-related cognitive decline through the modulation of pro-inflammatory state and decrease in amyloid burden
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Vitamin D mitigates age-related cognitive decline through the modulation of pro-inflammatory state and decrease in amyloid burden

机译：维生素D通过调节促炎状态和减少淀粉样蛋白负担减轻与年龄有关的认知能力下降

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Background Increasing evidence shows an association between the use of vitamin D and improvement in age-related cognitive decline. In this study, we investigated the possible mechanisms involved in the neuroprotective effects of vitamin D on age-related brain changes and cognitive function. Methods Male F344 rats aged 20 months (old) and 6 months (young) were used and randomly assigned to either vitamin D supplementation or no supplementation (control). A total of n = 39 rats were used in the study. Rats were individually housed and the supplementation group received a subcutaneous injection of vitamin D (1, α25-dihydroxyvitamin D3) 42 I.U./Kg for 21 days. Control animals received equal volume of normal saline. Behavioral testing in water maze and spontaneous object recognition tasks started on day 14. Levels of interleukin (IL)-1β and IL-10 were quantified to assess inflammatory state. Also, beta amyloid (Aβ) clearance and Aβ load were measured. Results Our results show that: (1) aged rats demonstrated significant learning and memory impairment overall compared to younger animals. However, the age-related decline in learning and memory was ameliorated by the supplementation of vitamin D. No vitamin D effect on learning and memory was seen in the young animals; 2) the pro-inflammatory cytokine IL-1β is significantly increased while the anti-inflammatory cytokine IL-10 is significantly decreased in the aged rats compared to the young animals; but this age-related change in inflammatory state was mitigated by vitamin D supplementation. No effects of vitamin D were seen on the IL-1β and IL-10 expression in the young rats; (3) vitamin D increased Aβ clearance and decreased amyloid burden in the aged rats while no significant difference was seen between the young animal groups. Conclusions Our data suggest that vitamin D supplementation modulated age-related increase in pro-inflammatory state and amyloid burden. It is possible that these effects of vitamin D mediated the decrease memory impairment seen in the aged rats making it a useful therapeutic option to alleviate the effects of aging on cognitive function.
机译：背景越来越多的证据表明，使用维生素D与改善与年龄有关的认知能力下降之间存在关联。在这项研究中，我们调查了维生素D对与年龄有关的大脑变化和认知功能的神经保护作用的可能机制。方法使用20个月（大）和6个月（年轻）的雄性F344大鼠，随机分配补充维生素D或不补充维生素D（对照组）。该研究总共使用了n = 39只大鼠。单独饲养大鼠，补充组皮下注射维生素D（1，α25-二羟基维生素D3）42 I.U./Kg，持续21天。对照动物接受等体积的生理盐水。在水迷宫中的行为测试和自发的物体识别任务从第14天开始。定量白介素（IL）-1β和IL-10的水平以评估炎症状态。而且，测量了β淀粉样蛋白（Aβ）的清除率和Aβ负荷。结果我们的结果表明：（1）与年幼动物相比，老年大鼠总体上表现出明显的学习和记忆障碍。然而，通过补充维生素D可以缓解与年龄有关的学习和记忆下降。在幼小的动物中，未见维生素D对学习和记忆的影响。 2）与年轻动物相比，老年大鼠的促炎细胞因子IL-1β显着升高，而抗炎细胞因子IL-10显着降低;但是通过补充维生素D可以缓解这种与年龄相关的炎症状态变化。没有观察到维生素D对幼鼠IL-1β和IL-10表达的影响; （3）维生素D增加了老年大鼠的Aβ清除率并降低了淀粉样蛋白负荷，而在幼年动物组之间则没有显着差异。结论我们的数据表明，补充维生素D可调节年龄相关的促炎状态和淀粉样蛋白负荷的增加。维生素D的这些作用可能介导了老年大鼠中记忆力减退的减少，使其成为减轻衰老对认知功能的影响的有效治疗选择。

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