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首页> 外文期刊>Journal of neuroinflammation >Evaluation of age-related changes in translocator protein (TSPO) in human brain using 11C-[R]-PK11195 PET
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Evaluation of age-related changes in translocator protein (TSPO) in human brain using 11C-[R]-PK11195 PET

机译：使用 11 C- [R] -PK11195 PET评价人脑中年龄相关的转运蛋白（TSPO）的变化

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Background We studied the distribution and expression of translocator protein in the human brain using 11C-[R]-PK-11195 positron emission tomography (PK11195 PET) and evaluated age-related changes. Methods A dynamic PK11195 PET scan was performed in 15 normal healthy adults (mean age: 29鈥壜?.5 years (range: 20 to 49); 7 males) and 10 children (mean age: 8.8鈥壜?.2 years (range: 1.2 to 17); 5 males), who were studied for potential neuroinflammation but showed no focally increased PK11195 binding. The PET images were evaluated by calculating standard uptake values and regional binding potential, based on a simplified reference region model, as well as with a voxel-wise analysis using statistical parametric mapping. Results PK11195 uptake in the brain is relatively low, compared with the subcortical structures, and symmetrical. The overall pattern of PK11195 distribution in the brain does not change with age. PK11195 uptake was lowest in the frontal-parietal-temporal cortex and highest in the pituitary gland, midbrain, thalamus, basal ganglia, occipital cortex, hippocampus and cerebellum, in descending order. White matter showed negligible PK11195 uptake. Overall, brain PK11195 uptake increased with age, with midbrain and thalamus showing relatively higher increases with age compared with other brain regions. Conclusions The brain shows low PK11195 uptake, which is lower in the cortex and cerebellum compared with subcortical structures, suggesting a low level of translocator protein expression. There is no hemispheric asymmetry in PK11195 uptake and the overall pattern of PK11195 distribution in the brain does not change with age. However, brain PK11195 uptake increases with age, with the thalamus and midbrain showing relatively higher increases compared with other brain regions. This increase in uptake suggests an age-related increase in translocator protein expression or the number of cells expressing these receptors or both.
机译：背景技术我们使用11C- [R] -PK-11195正电子发射断层扫描（PK11195 PET）研究人脑中易位蛋白的分布和表达，并评估了与年龄有关的变化。方法对15名正常健康成年人（平均年龄：29±0.5岁（范围：20至49岁）; 7名男性）和10名儿童（平均年龄：8.8±0.2岁）进行了动态PK11195 PET扫描。范围：1.2到17）; 5位男性），进行了潜在的神经炎症研究，但未发现PK11195的结合增加。通过基于简化的参考区域模型以及使用统计参数映射的体素分析，通过计算标准摄取值和区域结合潜力来评估PET图像。结果与大脑皮层下结构相比，PK11195在大脑中的摄取相对较低，并且对称。大脑中PK11195分布的总体模式不会随年龄变化。 PK11195摄取在额顶顶颞叶皮层中最低，而在垂体，中脑，丘脑，基底神经节，枕叶皮层，海马和小脑中以降序排列。白质显示出可忽略的PK11195吸收。总体而言，大脑PK11195的摄取量随年龄增长而增加，与其他大脑区域相比，中脑和丘脑的摄取量随年龄增长而相对较高。结论大脑的PK11195摄取较低，与皮层下结构相比，在皮质和小脑中的摄取较低，这表明转运蛋白的表达水平较低。 PK11195的摄取没有半球不对称性，并且大脑中PK11195分布的总体模式不会随年龄变化。但是，大脑PK11195的摄取随年龄增长而增加，丘脑和中脑与其他大脑区域相比显示出相对更高的增加。摄取的增加表明易位蛋白表达或表达这些受体的细胞数量或两者均与年龄有关。

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