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首页> 外文期刊>Journal of neuroinflammation >Exercise-induced hippocampal anti-inflammatory response in aged rats
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Exercise-induced hippocampal anti-inflammatory response in aged rats

机译：运动引起的老年大鼠海马抗炎反应

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Aging is often accompanied by cognitive decline, memory impairment and an increased susceptibility to neurodegenerative disorders. Most of these age-related alterations have been associated with deleterious processes such as changes in the expression of inflammatory cytokines. Indeed, higher levels of pro-inflammatory cytokines and lower levels of anti-inflammatory cytokines are found in the aged brain. This perturbation in pro- and anti-inflammatory balance can represent one of the mechanisms that contribute to age-associated neuronal dysfunction and brain vulnerability. We conducted an experimental study to investigate whether an aerobic exercise program could promote changes in inflammatory response in the brains of aged rats. To do so, we evaluated the levels of tumor necrosis factor alpha (TNFα), interleukin 1 beta (IL1β), interleukin 6 (IL6) and interleukin 10 (IL10) in the hippocampal formation of 18 month old rats that underwent treadmill training over 10 consecutive days. Quantitative immunoassay analyses showed that the physical exercise increased anti-inflammatory cytokine levels IL10 in the hippocampal formation of aged rats, when compared to the control group. The hippocampal levels of pro-inflammatory cytokines IL1β, IL6 and TNFα were not statistically different between the groups. However, a significant reduction in IL1β/IL10, IL6/IL10 and TNFα/IL10 ratio was observed in the exercised group in relation to the control group. These findings indicate a favorable effect of physical exercise in the balance between hippocampal pro- and anti-inflammatory during aging, as well as reinforce the potential therapeutic of exercise in reducing the risk of neuroinflammation-linked disorders.
机译：衰老通常伴随着认知能力下降，记忆力减退和对神经退行性疾病的敏感性增加。这些与年龄有关的变化大多数与有害过程有关，例如炎症细胞因子表达的变化。实际上，在衰老的大脑中发现了较高水平的促炎细胞因子和较低水平的抗炎细胞因子。促炎和抗炎平衡的这种紊乱可能是导致与年龄相关的神经元功能障碍和脑部脆弱性的机制之一。我们进行了一项实验研究，以研究有氧运动程序是否可以促进衰老大鼠大脑中炎症反应的变化。为此，我们评估了在18个月大的大鼠中经过10多次跑步训练的海马体中肿瘤坏死因子α（TNFα），白细胞介素1β（IL1β），白细胞介素6（IL6）和白细胞介素10（IL10）的水平。连续多日。定量免疫测定分析表明，与对照组相比，体育锻炼增加了衰老大鼠海马结构中抗炎细胞因子IL10的水平。两组之间海马促炎性细胞因子IL1β，IL6和TNFα的水平无统计学差异。然而，与对照组相比，在运动组中观察到IL1β/ IL10，IL6 / IL10和TNFα/ IL10比的显着降低。这些发现表明，体育锻炼对衰老过程中海马促炎和抗炎之间的平衡具有有益的作用，并增强了运动疗法的潜在疗效，可降低与神经炎症相关疾病的风险。

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