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首页> 外文期刊>Journal of Neurodegenerative Diseases >Bacopa monnieriPhytochemicals Mediated Synthesis of Platinum Nanoparticles and Its Neurorescue Effect on 1-Methyl 4-Phenyl 1,2,3,6 Tetrahydropyridine-Induced Experimental Parkinsonism in Zebrafish
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Bacopa monnieriPhytochemicals Mediated Synthesis of Platinum Nanoparticles and Its Neurorescue Effect on 1-Methyl 4-Phenyl 1,2,3,6 Tetrahydropyridine-Induced Experimental Parkinsonism in Zebrafish

机译：Bacopa monnieri光化学物质介导的铂纳米粒子的合成及其对1-甲基4-苯基1,2,3,6四氢吡啶诱导的斑马鱼实验性帕金森病的神经挽救作用

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Current discovery demonstrates the rapid formation of platinum nanoparticles using leaf extract of a neurobeneficial plant,Bacopa monnieri(BmE). The nanoparticles (BmE-PtNPs) were stabilized and then coated with varied phytochemicals present within the leaf extract. These nanoparticles demonstrated the same activity of Complex I, as that of oxidizing NADH to NAD+using a spectrophotometric method. This suggests that BmE-PtNPs are a potential medicinal substance for oxidative stress mediated disease with suppressed mitochondrial complex I, namely, Parkinson's disease (PD). Hence, the neuroprotective potentials of the phytochemical coated nanoparticle were explored in 1-methyl 4-phenyl 1,2,3,6 tetrahydropyridine- (MPTP-)induced experimental Parkinsonism in zebrafish model. BmE-PtNPs pretreatment significantly reversed toxic effects of MPTP by increasing the levels of dopamine, its metabolites, GSH and activities of GPx, catalase, SOD and complex I, and reducing levels of MDA along with enhanced locomotor activity. Taken together, these findings suggest that BmE-PtNPs have protective effect in MPTP-induced neurotoxicity in this model of Parkinson's disease via their dual functions as mitochondrial complex I and antioxidant activity.
机译：当前的发现表明，使用神经有益植物叶片紫苏（Bacopa monnieri，BmE）的叶提取物可以快速形成铂纳米颗粒。稳定纳米颗粒（BmE-PtNPs），然后用叶提取物中存在的各种植物化学物质包被。这些纳米颗粒表现出与配合物I相同的活性，与使用分光光度法将NADH氧化为NAD +的活性相同。这表明，BmE-PtNPs是潜在的线粒体复合物I被抑制的氧化应激介导的疾病，即帕金森氏病（PD）的药物。因此，在斑马鱼模型中的1-甲基4-苯基1,2,3,6四氢吡啶-（MPTP-）诱导的实验性帕金森病中探索了植物化学涂层纳米颗粒的神经保护潜力。 BmE-PtNPs预处理可通过增加多巴胺，其代谢产物，GSH和GPx，过氧化氢酶，SOD和复合物I的活性，并降低MDA的水平以及增强运动活性，来显着逆转MPTP的毒性作用。综上所述，这些发现表明，在这种帕金森氏病模型中，BmE-PtNPs具有线粒体复合体I和抗氧化活性的双重功能，对MPTP诱导的神经毒性具有保护作用。

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