首页> 外文期刊>Journal of Mid-Life Health >Multifocal superficial rapidly growing postirradiation sarcoma mimicking metastatic carcinoma
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Multifocal superficial rapidly growing postirradiation sarcoma mimicking metastatic carcinoma

机译:模拟转移性癌的多灶浅表快速生长的放射后肉瘤

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Radiation induced sarcomas (RIS) on cytology is rare however need to be reported as they are histologically distinct from the primary tumor and arise years after completion of the radiotherapy. Fine needle aspiration cytology is mostly indicated in cancer patients suspected of recurrence/metastasis and rarely in secondary tumors post therapy or irradiation. Depending on the morphology and site of occurrence of RIS they can cause diagnostic difficulty with the primary carcinoma or sarcoma that was irradiated. Here we discuss a 49 yr old lady, known and treated case of carcinoma cervix who presented with multiple nodular swellings in the lower back and gluteal region and had clinical impression of metastatic carcinoma. The fine needle aspiration cytology smears revealed pleomorphic spindle shaped cells with abundant mitotic figures. Extensive immunocytochemical work up was done on the smear and cell block which helped to make a final conclusion of radiation induced pleomorphic sarcoma. The diagnosis of a tumor in a proven case of previous malignancy needs consideration of tumors secondary to therapy as well, along with the diagnostic differentials of metastasis or recurrence.
机译:细胞学上辐射诱发的肉瘤(RIS)很少见,但由于其在组织学上与原发肿瘤不同,并且在放疗结束后数年内出现,因此需要进行报道。细针穿刺细胞学检查主要用于怀疑复发/转移的癌症患者,很少在治疗或放疗后的继发性肿瘤中使用。根据RIS的形态和发生部位,它们可能导致被照射的原发癌或肉瘤的诊断困难。在这里,我们讨论了一个49岁的老太太,已知和治疗过的宫颈癌病例,在下背部和臀区域出现多发结节性肿胀,并具有转移性癌的临床印象。细针穿刺细胞学涂片显示多形纺锤形细胞,有丝分裂丰富。对涂片和细胞块进行了广泛的免疫细胞化学检查,这有助于最终确定放射线诱发的多形性肉瘤。在既往恶性肿瘤的确诊病例中,肿瘤的诊断还需要考虑继发于治疗的肿瘤,以及转移或复发的诊断差异。

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