• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Neuroscience and Behavioral Health >Neuroprotective potential of Aframomum melegueta extracts on brain of monosodium glutamate-treated wistar albino rats
【24h】

Neuroprotective potential of Aframomum melegueta extracts on brain of monosodium glutamate-treated wistar albino rats

机译：阿魏提取物对味精处理的wistar白化病大鼠脑的神经保护作用。

获取原文
       
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The study evaluated the biochemical effects of methanolic seed extract of Aframomum melegueta (MEAM) on biochemical parameters of the brain of rats treated with monosodium glutamate (MSG) with a view to considering the possibility of using the plant as a remedy for the management of neurotoxic disorders. MEAM was prepared according to standard methods, phytochemically screened and followed by evaluation of its antioxidant and anti-inflammatory potentials as well as its biological activities. Phytochemical screening of the methanolic extract (ME) revealed the presence of alkaloids, cardiac glycosides, flavonoids, saponins, steroids, tannins and terpenoids. Administration of MSG (2 g/kg bwt) caused alterations in the levels of glutathione, nitric oxide, Vitamin C and E, as well as in the reduction of activities of enzymatic antioxidants. There were increases in the activities of brain marker enzymes, protein and peroxidation levels. Histopathological observations of brain sections revealed that MEAM protected the brain from glutamate-induced neurotoxicity. Conclusively, extract of A. melegueta elicited appreciable and potent neuroprotective potentials against neuro-degeneration caused by MSG oral administration, in a concentration dependent manner.
机译：这项研究评估了米曲霉（MEAM）的甲醇种子提取物对用谷氨酸钠（MSG）处理的大鼠脑的生化参数的生化作用，目的是考虑将这种植物用作治疗神经毒性药物的可能性。疾病。根据标准方法制备MEAM，对其进行植物化学筛选，然后评估其抗氧化和抗炎潜力以及其生物学活性。对甲醇提取物（ME）进行植物化学筛选后，发现存在生物碱，强心苷，类黄酮，皂角苷，类固醇，单宁和萜类化合物。施用味精（2 g / kg体重）会导致谷胱甘肽，一氧化氮，维生素C和E的含量发生变化，并导致酶促抗氧化剂的活性降低。脑标志物酶，蛋白质和过氧化水平的活性增加。对脑切片的组织病理学观察表明，MEAM可保护大脑免受谷氨酸诱导的神经毒性。结论是，米曲霉提取物以浓度依赖的方式引起了对抗由味精口服给药引起的神经变性的明显和有效的神经保护潜能。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号