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首页> 外文期刊>Journal of neurological sciences (Turkish) >Histological and Biochemical Findings In An Experimental Model of Intervertebral Disc Degeneration Based on Radio Frequency
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Histological and Biochemical Findings In An Experimental Model of Intervertebral Disc Degeneration Based on Radio Frequency

机译：基于射频的椎间盘退变实验模型的组织学和生化发现

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The aim of this study is to develop an disc degeneration animal model which can be standardized, easy performed and which gives quickly results by using radiofrequency. For disc degeneration New Zealand rabbits were used. Animals were divided into three groups. First group was control. The second group was examined histological 15 days after the experiment for the early period findings. The last group was examined histological and biochemical 30 days after the experiment. Nucleoplasty device was applied to different disc levels in different doses. For histological evaluation, chondrocyt like cells were numbered and thicknesses of the collagen fibrils were measured in the nucleosus pulposus. Biochemically, collagen weight and percentage decrease in liquid content of nucleosus pulposus were measured. When the results of the study groups were compared with the controls, thickened collagen bands and increased number of chondrocyt like cells were detected in favour of the study groups 15 days after the experiment. Microscopic measurements of intervertebral disc were statistically significantly increased on the 30th day of the experiment compared with the 15th day results (p<0.05). As biochemical, statistically significantly reduced in the amount of collagen and percentage decrease in the liquid content of nucleus pulposus in study groups compared with the controls support degeneration(p<0.05). Our study group suggests that use of radiofrequency which was applied in a disc degeneration model is an effective, reliable and quick method and our model will help future molecular studies of disc degeneration.How to cite this article:G. ERB?L, C. YURTSEVER, ü. S?NMEZ, P. AKAN, K. YüCESOY, S. ?ZBAL: An Experimental Model of Intervertebral Disc Degeneration Based on Radio Frequency. J Neurol Sci [Turk] 2008;25:208-219How to cite this URL & PDF:G. ERB?L, C. YURTSEVER, ü. S?NMEZ, P. AKAN, K. YüCESOY, S. ?ZBAL: An Experimental Model of Intervertebral Disc Degeneration Based on Radio Frequency. J Neurol Sci [Turk] 2008 [cited 2008 December 26];25:208-219. Available from: http://jns.dergisi.org/text.php3?id=235 PDF: http://jns.dergisi.org/pdf/pdf_JNS_235.pdfE-mail of the corresponding author: guven.erbil@deu.edu.tr
机译：这项研究的目的是开发一种圆盘变性动物模型，该模型可以标准化，易于执行并且可以通过使用射频快速得出结果。对于椎间盘退变，使用新西兰兔。将动物分为三组。第一组是对照组。实验后15天，对第二组进行了组织学检查，以了解早期发现。实验后30天，对最后一组进行组织学和生化检查。核移植装置以不同的剂量应用于不同的椎间盘水平。为了进行组织学评估，对软骨样细胞进行编号，并在髓核中测量胶原纤维的厚度。生化方面，测量了胶原蛋白的重量和核仁液体含量的百分比降低。当将研究组的结果与对照进行比较时，发现在实验后15天，有利于研究组的胶原蛋白条带增加了，软骨细胞样细胞的数量增加了。与第15天的结果相比，在实验的第30天，椎间盘的显微测量在统计学上显着增加（p <0.05）。作为生化指标，与对照组相比，研究组的胶原蛋白含量明显减少，髓核液体含量减少百分比，具有统计学意义（p <0.05）。我们的研究小组认为，在椎间盘退变模型中使用射频是一种有效，可靠和快速的方法，我们的模型将有助于将来椎间盘退变的分子研究。 ERB？L，C。YURTSEVER，ü。 S？NMEZ，P。AKAN，K.YüCESOY，S。？ZBAL：基于射频的椎间盘退变的实验模型。 J Neurol Sci [Turk] 2008; 25：208-219如何引用此URL和PDF：G。 ERB？L，C。YURTSEVER，ü。 S？NMEZ，P。AKAN，K.YüCESOY，S。？ZBAL：基于射频的椎间盘退变的实验模型。神经科学杂志（Turk）2008年[引自2008年12月26日]; 25：208-219。可从以下网址获得：http://jns.dergisi.org/text.php3?id=235 PDF：http://jns.dergisi.org/pdf/pdf_JNS_235.pdf相应作者的电子邮件：guven.erbil@deu。教育

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