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首页> 外文期刊>Journal of neurological sciences (Turkish) >Role of Kv7 Potassium Channels in The Morphine-Induced Antinociception in Acute and Neuropathic Pain
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Role of Kv7 Potassium Channels in The Morphine-Induced Antinociception in Acute and Neuropathic Pain

机译：Kv7钾通道在吗啡诱导的急性和神经性疼痛镇痛中的作用

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Objective: We aimed to investigate the role of Kv7 potassium channels in the morphine-induced antinociception in both acute and neuropathic pain models.Methods: Neuropathic pain was induced by partial ligation of the right sciatic nerve. For intracerebroventricular (i.c.v.) injections, each rat was equipped with a permanent cannula. The response to painful thermal stimuli was assessed by the tail-flick test. In sciatic nerve-ligated rats, thermal hyperalgesia was assessed by paw withdrawal latencies in the plantar test and the mechanical hyperalgesia was determined by rigid von Frey filaments.Results: Rats received morphine (2, 5, 20 μg/10 μl; i.c.v.) or saline (10 μl; i.c.v.) 15 min before the tests. In all tests, morphine produced significant antinociceptive effect. When a Kv7 potassium channel blocker, linopirdine (0.1, 1, 10 μg/10 μl; i.c.v.) was administered 15 min before morphine, the effect of i.c.v. morphine in the tail-flick test and plantar test but not in the test with von Frey filaments were prevented.Conclusions: Kv7 potassium channels contribute to the effect of i.c.v. morphine on acute pain induced by thermal stimulation. In the sciatic nerve-ligated rats, these channels play role in the effect of morphine on thermal hyperalgesia, but not on mechanical hyperalgesia.
机译：目的：我们探讨在急性和神经性疼痛模型中，Kv7钾通道在吗啡诱导的抗伤害感受中的作用。方法：右结坐骨神经部分结扎可引起神经性疼痛。对于脑室内（i.c.v.）注射，每只大鼠均配备永久性插管。通过甩尾试验评估对疼痛的热刺激的反应。在坐骨神经结扎的大鼠中，通过足底试验中的爪退缩潜伏期评估热痛觉过敏，并通过刚性冯弗雷丝确定机械性痛觉过敏。结果：大鼠接受吗啡（2、5、20μg/ 10μl; icv）或测试前15分钟加入生理盐水（10μl; icv）。在所有测试中，吗啡产生了显着的抗伤害作用。当在吗啡给药前15分钟服用Kv7钾通道阻滞剂利诺吡丁（0.1，1，10μg/ 10μl;静脉注射），静脉注射的效果吗啡在尾部甩动试验和足底试验中被阻止，但在冯·弗雷细丝试验中没有被阻止。结论：Kv7钾通道有助于静脉内注射。吗啡对热刺激引起的急性疼痛。在坐骨神经结扎的大鼠中，这些通道在吗啡对热痛觉过敏的作用中起作用，但对机械痛觉过敏没有作用。

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