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Anxiogenic potential of prulifloxacin in experimental animal model

机译:普鲁沙星在实验动物模型中的血管生成潜力

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Prulifloxacin, the prodrug of ulifloxacin, is a broad spectrum oral fluoroquinolones antibacterial agent. Fluoroquinolones have been used for the treatment of bacterial infection for many years. Although they were considered as relatively safe drugs, various adverse effects have recently been reported along with increase in the usage of new generation fluoroquinolones. In the present study, prulifloxacin 200 and 400 mg/kg were screened on anxiety parameter in mice. Our result suggested that prulifloxacin (200 and 400 mg/kg) exerted anxiety-like effect in the elevated plus maze, hole board apparatus and light/dark exploration test in mice.
机译:普利沙星是奥利沙星的前药,是一种广谱口服氟喹诺酮类抗菌剂。氟喹诺酮类已用于治疗细菌感染多年。尽管它们被认为是相对安全的药物,但随着新一代氟喹诺酮类药物的使用增加,最近已报道了各种不良反应。在本研究中,对普利沙星200和400 mg / kg的小鼠焦虑参数进行了筛选。我们的研究结果表明,普鲁沙星(200和400 mg / kg)在高架迷宫,孔板仪器和光/暗探测实验中表现出焦虑样作用。

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