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首页> 外文期刊>Journal of Oncology Practice >Low Enrollment of Adolescents and Young Adults Onto Cancer Trials: Insights From the Community Clinical Oncology Program
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Low Enrollment of Adolescents and Young Adults Onto Cancer Trials: Insights From the Community Clinical Oncology Program

机译：青少年和年轻人的低入学率：来自社区临床肿瘤学计划的见解

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AbstractPurpose:Stagnant outcomes for adolescents and young adults (AYAs; 15 to 39 years old) with cancer are partly attributed to poor enrollment onto clinical trials. The National Cancer Institute (NCI) Community Clinical Oncology Program (CCOP) was developed to improve clinical trial participation in the community setting, where AYAs are most often treated. Further, many CCOP sites had pediatric and medical oncologists with collaborative potential for AYA recruitment and care. For these reasons, we hypothesized that CCOP sites enrolled proportionately more AYAs than non-CCOP sites onto Children’s Oncology Group (COG) trials.Methods:For the 10-year period 2004 through 2013, the NCI Division of Cancer Prevention database was queried to evaluate enrollments into relevant COG studies. The proportional enrollment of AYAs at CCOP and non-CCOP sites was compared and the change in AYA enrollment patterns assessed. All sites were COG member institutions.Results:Although CCOP sites enrolled a higher proportion of patients in cancer control studies than non-CCOP sites (3.5% v 1.8%; P .001), they enrolled a lower proportion of AYAs (24.1% v 28.2%, respectively; P .001). Proportional AYA enrollment at CCOP sites decreased during the intervals 2004 through 2008 and 2009 through 2013 (26.7% v 21.7%; P .001).Conclusion:Despite oncology practice settings that might be expected to achieve otherwise, CCOP sites did not enroll a larger proportion of AYAs in clinical trials than traditional COG institutions. Our findings suggest that the CCOP (now the NCI Community Oncology Research Program) can be leveraged for developing targeted interventions for overcoming AYA enrollment barriers.
机译：摘要目的：青少年和15岁至39岁的年轻人（AYAs）的停滞结局部分归因于临床试验入学率低。美国国家癌症研究所（NCI）社区临床肿瘤学计划（CCOP）的开发是为了改善临床环境中对AYA的治疗最为普遍的社区中的临床试验参与度。此外，许多CCOP站点都有儿科和医学肿瘤学家，他们在AYA招募和护理方面具有合作潜力。基于这些原因，我们假设在儿童肿瘤学组（COG）试验中，CCOP站点招募的AYA比例比非CCOP站点的比例高。参加相关的COG研究。比较了在CCOP和非CCOP站点上AYA的按比例录取，并评估了AYA录取模式的变化。结果：尽管在癌症控制研究中，CCOP站点招募的患者比例高于非CCOP站点（3.5％vs 1.8％; P <.001），但他们参与的AYA比例较低（24.1％） v分别为28.2％; P <.001）。在2004年至2008年和2009年至2013年的间隔期间，CCOP站点的比例AYA入学率下降（26.7％v 21.7％; P <.001）。结论：尽管可以预期实现肿瘤学实践设置，但CCOP站点并未入组与传统的COG机构相比，临床试验中AYA的比例更大。我们的发现表明，可以利用CCOP（现为NCI社区肿瘤学研究计划）来开发针对性干预措施，以克服AYA入学障碍。

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