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首页> 外文期刊>Journal of Optometry >Aging and topical pilocarpine concentrations effects on pupil size and tear flow rate
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Aging and topical pilocarpine concentrations effects on pupil size and tear flow rate

机译：老化和局部毛果芸香碱浓度对瞳孔大小和泪液流速的影响

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Purpose: This is to evaluate the effects of age and different concentrations of pilocarpine on tear flow rate and pupil size. Methods: The tear flow rates and pupil sizes of eighty-one volunteers were measured with Schimer's strips and a meter rule gauge, respectively. These procedures were also employed in testing the effects of 2 % and 4 % concentrations of pilocarpine on tear secretion and pupil constriction. Results: There were significant differences between the initial mean tear flow rate and the mean tear flow rates after the installation of 2 % pilocarpine (critical t=1.96 and calculated t=6.46) and 4 % pilocarpine (calculated t=8.83). There were no significant differences in the initial tear flow rates between the sexes. There were significant differences between the mean tear flow rates obtained with 2 % and 4 % concentrations of pilocarpine (calculated t=3.41). The mean initial tear flow rate for the eighty-one volunteers was 13.84mm +/- 1.19 (SD).There were significant differences between the mean initial pupil size 2.96mm +/- 1.04 (SD) and the mean pupil sizes 2.38mm +/- 1.11(SD) after the instillation of 2 % pilocarpine (Critical t=1.96 and calculated t=2.46). Conclusion: The basal tear flow rate decreased with advancing age and topical pilocarpine increased tears secretion in all the age groups. The age groups (31 years and above) were more tolerant to the stinging effect of pilocarpine and induced reduced pupil sizes, but there were no significant differences between the mean pupil sizes obtained with the pilocarpine concentrations.
机译：目的：这是为了评估年龄和不同浓度的毛果芸香碱对泪液流速和瞳孔大小的影响。方法：分别用Schimer试纸条和米尺测量八十一名志愿者的泪水流速和瞳孔大小。这些程序还用于测试2％和4％浓度的毛果芸香碱对泪液分泌和瞳孔收缩的影响。结果：初始平均泪液流速与安装2％毛果芸香碱（临界t = 1.96，计算得出的t = 6.46）和4％毛果芸香碱（计算得出的t = 8.83）之后的平均撕裂流速之间存在显着差异。男女之间的初始泪液流速没有显着差异。在使用浓度为2％和4％的毛果芸香碱时获得的平均泪液流速之间存在显着差异（计算得出的t = 3.41）。 81名志愿者的平均初始泪液流速为13.84mm +/- 1.19（SD），平均初始瞳孔大小2.96mm +/- 1.04（SD）与平均瞳孔大小2.38mm +之间存在显着差异-滴注2％毛果芸香碱后的1.11（SD）（临界t = 1.96，计算得出的t = 2.46）。结论：随着年龄的增长，基础泪液流速降低，而局部毛果芸香碱在所有年龄组中均增加了泪液分泌。年龄组（31岁及以上）对毛果芸香碱的刺痛效果更耐受，并诱发瞳孔尺寸减小，但在毛果芸香碱浓度下获得的平均瞳孔尺寸之间没有显着差异。

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