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首页> 外文期刊>Journal of Ophthalmology >Efficacy and Safety of Corneal Transplantation Using Corneas from Foreign Donors versus Domestic Donors: A Prospective, Randomized, Controlled Trial
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Efficacy and Safety of Corneal Transplantation Using Corneas from Foreign Donors versus Domestic Donors: A Prospective, Randomized, Controlled Trial

机译：使用外国捐赠者和国内捐赠者进行角膜移植的角膜移植的功效和安全性：一项前瞻性，随机对照试验

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Purpose. To assess the efficacy and safety of corneal transplantation using corneas from foreign donors.Methods. One hundred and eight patients needing therapeutic penetrating keratoplasty were randomly divided into 2 groups (54 cases/group): foreign group using foreign donor corneas and domestic group using domestic donor corneas. Clinical outcome and incidence of postoperative complications were compared between groups.Results. No significant difference with respect to the therapeutic outcome and postoperative Best Corrected Visual Acuity (BCVA) and neovascularization by final follow-up was observed between the two groups. The graft thickness in the foreign group was statistically higher than the domestic group at 1 month postoperatively, but not at 3, 6, and 12 months postoperatively. Corneal endothelial cell density in the domestic group was statistically higher than in the foreign group at 3, 6, and 12 months postoperatively. Corneal epithelial abnormalities in the foreign group were significantly higher than that in domestic group. The primary graft failure, incidence of graft survival, and postoperative complications such as immunologic rejection, graft infection, and secondary glaucoma were not significantly different between the two groups.Conclusions. Corneal transplantations using foreign donor corneas are as effective and safe as those using domestic donor corneas.
机译：目的。评估使用外国捐献者的角膜进行角膜移植的疗效和安全性。将需要治疗性穿透性角膜移植的108例患者随机分为2组（54例/组）：使用外来供体角膜的外国组和使用内供体角膜的国内组。比较两组患者的临床结局和术后并发症发生率。两组之间在治疗效果和术后最佳矫正视力（BCVA）和新血管形成方面均无显着差异。术后1个月，国外组的移植物厚度在统计学上高于国内组，但术后3、6和12个月则没有。术后3、6和12个月，国内组的角膜内皮细胞密度在统计学上高于国外组。国外组角膜上皮异常明显高于国内组。两组之间的原发性移植失败，移植物存活率以及术后并发症如免疫排斥，移植物感染和继发性青光眼无显着差异。使用外国供体角膜的角膜移植与使用国内供体角膜的角膜移植一样有效和安全。

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