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首页> 外文期刊>Journal of Molecular Psychiatry >Effects of physical exercise on central nervous system functions: a review of brain region specific adaptations
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Effects of physical exercise on central nervous system functions: a review of brain region specific adaptations

机译：体育锻炼对中枢神经系统功能的影响：脑区域特定适应的综述。

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Pathologies of central nervous system (CNS) functions are involved in prevalent conditions such as Alzheimer’s disease, depression, and Parkinson’s disease. Notable pathologies include dysfunctions of circadian rhythm, central metabolism, cardiovascular function, central stress responses, and movement mediated by the basal ganglia. Although evidence suggests exercise may benefit these conditions, the neurobiological mechanisms of exercise in specific brain regions involved in these important CNS functions have yet to be clarified. Here we review murine evidence about the effects of exercise on discrete brain regions involved in important CNS functions. Exercise effects on circadian rhythm, central metabolism, cardiovascular function, stress responses in the brain stem and hypothalamic pituitary axis, and movement are examined. The databases Pubmed, Web of Science, and Embase were searched for articles investigating regional brain adaptations to exercise. Brain regions examined included the brain stem, hypothalamus, and basal ganglia. We found evidence of multiple regional adaptations to both forced and voluntary exercise. Exercise can induce molecular adaptations in neuronal function in many instances. Taken together, these findings suggest that the regional physiological adaptations that occur with exercise could constitute a promising field for elucidating molecular and cellular mechanisms of recovery in psychiatric and neurological health conditions.
机译：中枢神经系统（CNS）功能的病理学涉及诸如阿尔茨海默氏病，抑郁症和帕金森氏病等普遍疾病。值得注意的病理包括昼夜节律功能紊乱，中枢新陈代谢，心血管功能，中枢应激反应和基底神经节介导的运动。尽管有证据表明运动可能有益于这些状况，但尚未阐明运动中涉及这些重要中枢神经系统功能的特定大脑区域的神经生物学机制。在这里，我们回顾了有关运动对参与重要中枢神经系统功能的离散大脑区域的影响的小鼠证据。检查运动对昼夜节律，中枢代谢，心血管功能，脑干和下丘脑垂体轴的应激反应以及运动的影响。在Pubmed，Web of Science和Embase数据库中搜索了研究区域大脑适应运动的文章。检查的大脑区域包括脑干，下丘脑和基底神经节。我们发现了对强迫和自愿运动进行多种区域适应的证据。在许多情况下，运动可以诱导神经元功能的分子适应。综上所述，这些发现表明，随着运动而发生的局部生理适应可能成为阐明精神和神经健康状况中恢复分子和细胞机制的有前途的领域。

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