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首页> 外文期刊>Journal of Nursing Education and Practice >Effects of exercise on cancer related fatigue in adults: A literature review and meta-analysis of randomized controlled trials
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Effects of exercise on cancer related fatigue in adults: A literature review and meta-analysis of randomized controlled trials

机译：运动对成人癌症相关疲劳的影响：随机对照试验的文献综述和荟萃分析

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Cancer related fatigue (CRF) is one among the common distressing symptoms experienced by cancer patients. Evidence showed that exercise interventions are effective in decreasing CRF. This review is to evaluate the evidence of the effectiveness of exercise interventions on CRF among adults with varied types of cancer in all phases of the cancer trajectory. A literature review with meta-analysis of randomized controlled trials (RCTs) was conducted. The results of RCTs (n = 20) that examined the effects of exercise on CRF were combined using two approaches: meta-analysis (n = 18) and summative analysis (n = 2). A summary effects size of the standardized mean difference (SMD) with 95% confidence intervals was calculated using random effects model and heterogeneity was assessed with the I2 statistic. The results showed overall, a small but significant decrease in the level of CRF (SMD, -0.32; 95% CI, -0.51 to -0.12; p = .002) was observed following exercise intervention. Subgroup analyses showed that both mixed modes (combination of resistance and aerobic exercises) and aerobic exercises were effective in significantly reducing CRF (p = .033; p = .046 respectively). The results indicated substantial heterogeneity between studies (I2 = 79%; p ≤ .0001). Summative analysis also suggested that exercise may be effective in reducing CRF. In conclusion, both resistance and aerobic exercises may be effective in decreasing CRF in adult patients. The result needs to be interpreted with caution due to considerable between-study heterogeneity.
机译：癌症相关的疲劳（CRF）是癌症患者常见的令人困扰的症状之一。有证据表明，运动干预可有效降低CRF。这篇综述旨在评估在癌症轨迹的所有阶段中，患有各种类型癌症的成年人对CRF进行运动干预的有效性的证据。通过随机对照试验（RCT）的荟萃分析进行文献综述。使用两种方法将检验运动对CRF的影响的RCT（n = 20）的结果结合起来：荟萃分析（n = 18）和总结分析（n = 2）。使用随机效应模型计算具有95％置信区间的标准化均值差（SMD）的总效应量，并使用I2统计量评估异质性。结果表明，在进行运动干预后，总体上观察到CRF的水平有小幅但显着的下降（SMD，-0.32; 95％CI，-0.51至-0.12; p = .002）。亚组分析显示，混合模式（阻力和有氧运动的组合）和有氧运动均可有效降低CRF（分别为p = .033; p = .046）。结果表明研究之间存在很大的异质性（I2 = 79％; p≤.0001）。汇总分析还表明，运动可能有效降低CRF。总之，抵抗运动和有氧运动均可有效降低成年患者的CRF。由于大量的研究间异质性，需要谨慎解释结果。

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