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首页> 外文期刊>Journal of Pain Research >Changes in pain and concurrent pain medication use following compounded topical analgesic treatment for chronic pain: 3- and 6-month follow-up results from the prospective, observational Optimizing Patient Experience and Response to Topical Analgesics study
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Changes in pain and concurrent pain medication use following compounded topical analgesic treatment for chronic pain: 3- and 6-month follow-up results from the prospective, observational Optimizing Patient Experience and Response to Topical Analgesics study

机译：复合式局部止痛药治疗慢性疼痛后疼痛的变化和同时使用止痛药的变化：前瞻性，观察性，优化患者体验和对局部止痛药研究的反应的3个月和6个月随访结果

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Background: Opioids and other controlled substances prescribed for chronic pain are associated with abuse, addiction, and death, prompting national initiatives to identify safe and effective pain management strategies including topical analgesics. Methods: This prospective, observational study evaluated changes from baseline in overall mean severity and interference scores on the Brief Pain Inventory scale and the use of concurrent pain medications at 3- and 6-month follow-up assessments in chronic pain patients treated with topical analgesics. Changes in pain severity and interference and medication usage were compared between treated patients and unmatched and matched controls. Results: The unmatched intervention group (unmatched-IG) included 631 patients who completed baseline and 3-month follow-up surveys (3-month unmatched-IG) and 158 who completed baseline and 6-month follow-up assessments (6-month unmatched-IG). Baseline and 3-month follow-up data were provided by 76 unmatched controls and 76 matched controls (3-month unmatched-CG and matched-CG), and 51 unmatched and 36 matched patients completed baseline and 6-month follow-up surveys (6-month unmatched-CG and matched-CG). Baseline demographic characteristics and mean pain severity and interference scores were similar between groups. There were statistically significant decreases from baseline in mean pain severity and interference scores within the 3- and 6-month unmatched-IG (all P <0.001). Significantly greater decreases in the mean change from baseline in pain severity and interference scores were evident for the 3- and 6-month unmatched-IG versus unmatched-CG (all P <0.001), with similar results when the 3- and 6-month matched-IG and matched-CG were compared. A higher percentage of the 3- and 6-month unmatched-IG and matched-IG de-escalated use of concurrent pain medications (all P <0.001), while significantly higher percentages of the unmatched-CG and matched-CG escalated medication use. Side effects were reported by <1% of the unmatched-IG. Conclusion: Topical analgesics appear to be effective and safe for the treatment of chronic pain, with randomized controlled trials needed to confirm these findings.
机译：背景：阿片类药物和其他用于慢性疼痛的受控物质与滥用，成瘾和死亡相关，促使国家制定了包括局部镇痛药在内的安全有效的疼痛管理策略。方法：这项前瞻性观察性研究评估了局部疼痛镇痛剂治疗的慢性疼痛患者在3个月和6个月的随访评估中，在简明疼痛量表上评估了总体平均严重度和干扰评分与基线水平相比的变化，以及同时使用止痛药的情况。 。比较了治疗患者与不匹配和匹配对照者的疼痛严重程度，干扰和用药情况的变化。结果：无配对干预组（无配对IG）包括631名完成基线和3个月随访调查的患者（3个月无配对IG）和158名完成基线和6个月随访评估（6个月）的患者无与伦比的IG）。由76位不匹配的对照和76位匹配的对照（3个月不匹配的CG和匹配的CG）提供了基线和3个月的随访数据，并且51位不匹配和36位匹配的患者完成了基线和6个月的随访调查（ 6个月不匹配CG和匹配CG）。两组之间的基线人口统计学特征，平均疼痛程度和干扰评分相似。在3个月和6个月不匹配IG期间，平均疼痛严重程度和干扰评分与基线相比有统计学显着下降（所有P <0.001）。 3和6个月不匹配IG与不匹配CG相比，疼痛严重度和干扰评分的平均值从基线的平均下降显着更大（所有P <0.001），当3个月和6个月时，结果相似比较了matched-IG和matched-CG。 3个月和6个月不匹配IG和匹配IG的同时使用止痛药的比例上升（所有P <0.001），而不匹配CG和匹配CG的递增药物的使用比例明显更高。据报道，未匹配IG的副作用小于1％。结论：外用镇痛药似乎对慢性疼痛的治疗有效且安全，需要进行随机对照试验来证实这些发现。

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