Aberrant Drug-Related Behavior Observed During Clinical Studies Involving Patients Taking Chronic Opioid Therapy for Persistent Pain and Fentanyl Buccal Tablet for Breakthrough Pain

Steven D. Passik; John Messina; Anthony Golsorkhi; Fang Xie

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Aberrant Drug-Related Behavior Observed During Clinical Studies Involving Patients Taking Chronic Opioid Therapy for Persistent Pain and Fentanyl Buccal Tablet for Breakthrough Pain

机译：在临床研究中观察到与药物相关的异常行为，涉及长期服用阿片类药物治疗持续性疼痛和芬太尼颊片治疗突破性疼痛的患者

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ContextInformation on aberrant drug-related behaviors in the clinical study setting is limited.ObjectivesThis retrospective analysis was designed to identify the types and frequency of aberrant drug-related behaviors (including misuse and abuse) and assoc

机译：在临床研究中，有关药物异常行为的信息是有限的。目的这项回顾性分析旨在确定药物异常行为（包括滥用和滥用）和不良反应的类型和频率。

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《Journal of pain and symptom management.》 |2011年第1期|共10页
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Steven D. Passik; John Messina; Anthony Golsorkhi; Fang Xie;
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1. Aberrant Drug-Related Behavior Observed During Clinical Studies Involving Patients Taking Chronic Opioid Therapy for Persistent Pain and Fentanyl Buccal Tablet for Breakthrough Pain [J] . Steven D. Passik John Messina Anthony Golsorkhiand Fang Xie Journal of pain and symptom management. . 2011,第1期

机译：在临床研究中观察到与药物相关的异常行为，涉及长期服用阿片类药物治疗持续性疼痛和芬太尼颊片治疗突破性疼痛的患者
2. Aberrant drug-related behavior observed during a 12-week open-label extension period of a study involving patients taking chronic opioid therapy for persistent pain and fentanyl buccal tablet or traditional short-acting opioid for breakthrough pain [J] . PassikS.D., NarayanaA., YangR. Pain medicine : . 2014,第8期

机译：在一项为期12周的开放标签扩展研究中观察到的与药物异常有关的行为，该研究涉及接受持续阿片类药物持续性疼痛和芬太尼颊片剂或传统短效阿片类药物治疗突破性疼痛的患者
3. A novel 12-week study, with three randomized, double-blind placebo-controlled periods to evaluate fentanyl buccal tablets for the relief of breakthrough pain in opioid-tolerant patients with noncancer-related chronic pain. [J] . Farrar JT, Messina J, Xie F, Pain medicine : . 2010,第9期

机译：一项为期12周的新颖研究，包括三个随机，双盲安慰剂对照期，用于评估芬太尼颊片对阿片耐受性非癌相关性慢性疼痛患者的突破性疼痛的缓解作用。
4. HIGH INTENSITY LASER THERAPY - A SOLUTION TO THE EPIDEMIC OF OPIOID PRESCRIPTION ABUSE FOR ACUTE AND CHRONIC PAIN [C] . Edwin Barry International Laser Safety Conference . 2017

机译：高强度激光疗法 - 急性和慢性疼痛的阿片类药物处方滥用疫情的解决方案
5. Exploring Nurse Anesthetists' Clinical Decision-Making in Perioperative Pain Management of Opioid-Dependent Patients with Chronic Pain [D] . Aultman, Tatyana. 2017

机译：探索护士麻醉师的围手术疼痛管理临床决策，依赖于阿片类药物依赖性患者的慢性疼痛
6. Breakthrough pain management using fentanyl buccal tablet (FBT) in combination with around-the-clock (ATC) opioids based on the efficacy and safety of FBT and its relationship with ATC opioids: results from an open-label multi-center study in Japanese cancer patients with detailed evaluation [O] . Chizuko Takigawa, Fumio Goto, Shigeru Tanda, -1

机译：结合芬太尼颊片剂（FBT）和全天候（ATC）阿片类药物的突破性疼痛管理基于FBT的功效和安全性及其与ATC阿片类药物的关系：一项来自于美国的开放标签多中心研究的结果日本癌症患者详细评估
7. Aberrant Drug-Related Behavior Observed During Clinical Studies Involving Patients Taking Chronic Opioid Therapy for Persistent Pain and Fentanyl Buccal Tablet for Breakthrough Pain [O] . Steven D. Passik, John Messina, Anthony Golsorkhi, 2011

机译：在涉及服用慢性阿片类药物治疗的临床研究期间观察到的异常药物相关行为对持续疼痛和芬太尼患者的突破性疼痛

Aberrant Drug-Related Behavior Observed During Clinical Studies Involving Patients Taking Chronic Opioid Therapy for Persistent Pain and Fentanyl Buccal Tablet for Breakthrough Pain

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