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首页> 外文期刊>Journal of Oral Microbiology >Effect of azithromycin on a red complex polymicrobial biofilm
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Effect of azithromycin on a red complex polymicrobial biofilm

机译：阿奇霉素对红色复合微生物生物膜的影响

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Azithromycin has recently gained popularity for the treatment of periodontal disease, despite sparse literature supporting efficiency in treating periodontal bacterial biofilms. The aim of this study was to evaluate the effect of azithromycin on biofilms comprised of Porphyromonas gingivalis, Treponema denticola, and Tannerella forsythia in comparison to an amoxicillin and metronidazole combination. P. gingivalis W50, T. denticola ATCC35405, and T. forsythia ATCC43037 grown under anaerobic conditions at 37°C were aliquoted into 96-well flat-bottom plates in different combinations with addition of azithromycin or amoxicillin?+?metronidazole at various concentrations. For the biofilm assay, the plates were incubated at 37°C anaerobically for 48?h, after which the biofilms were stained with crystal violet and measured for absorbance at AU620. In this model, polymicrobial biofilms of P. gingivalis?+?T. denticola, P. gingivalis?+?T. forsythia, and T. denticola?+?T. forsythia were cultured. Combination ...
机译：尽管文献稀少，但阿奇霉素在牙周疾病的治疗中已广受欢迎，尽管文献支持治疗牙周细菌生物膜的功效。这项研究的目的是评估阿奇霉素对与阿莫西林和甲硝唑联用的生物膜的影响，该生物膜包括牙龈卟啉单胞菌，齿状密螺旋体和连翘单胞菌。将在厌氧条件下于37°C生长的牙龈卟啉单胞菌W50，齿状锥虫（T. denticola）ATCC35405和连翘锥虫（T. Forsythia）ATCC43037等分到不同组合的96孔平底平板中，加入不同浓度的阿奇霉素或阿莫西林？+？甲硝唑。对于生物膜测定，将平板在37°C下厌氧孵育48？h，然后将生物膜用结晶紫染色，并在AU620处测量吸光度。在该模型中，牙龈卟啉单胞菌α+βT的微生物生物膜。 Denticola，P. gingivalis？+？T。连翘和T. denticola？+？T。连翘被培养。组合...

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