...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Oral Microbiology >Bacteriophages targeting Enterococcus faecalis strains - a potential new root canal therapy
【24h】

Bacteriophages targeting Enterococcus faecalis strains - a potential new root canal therapy

机译：针对粪肠球菌菌株的噬菌体-一种潜在的新根管治疗

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The most common isolated species from recalcitrant endodontic infections is Enterococcus faecalis, a gram positive multiply drug-resistant and environmentally stable bacterium. As a potential route to a biological solution to E. faecalis root-canal infection we aimed to isolate, characterise and test in vitro a range of lytic bacteriophages targeted against E. faecalis isolates from oral endodontic infections obtained from labs across Europe.Five bacteriophages were isolated from concentrated waste water named (SHEF2,4,5,6,7) that belong to the Siphoviridae family. They are specific to E. faecalis with genome sizes ranging from 39-43kb. Full chromosome sequences of SHEF2,4 and 5 alongside biological evidence revealed that they are lytic bacteriophages which place them as suitable candidate for therapy. We tested the ability of these phages to eradicate biofilm from abiotic surfaces and a novel cross-sectional tooth model while also showing that they are able to rescue Zebrafish embryos from E. fae...
机译：顽固性牙髓感染最常见的分离种是粪肠球菌，这是一种革兰氏阳性多重耐药性和环境稳定细菌。作为解决粪肠球菌根管感染生物方法的潜在途径，我们旨在分离，表征和体外测试一系列从欧洲实验室获得的口腔牙髓感染的针对粪肠球菌分离物的裂解性噬菌体。分离自名为Siphoviridae家族的浓缩废水（SHEF2,4,5,6,7）。它们特异于粪肠球菌，基因组大小在39-43kb之间。 SHEF2,4和5的完整染色体序列以及生物学证据表明，它们是裂解性噬菌体，使其成为适合治疗的候选物。我们测试了这些噬菌体从非生物表面清除生物膜的能力和新颖的横断面牙齿模型，同时还表明它们能够从大肠杆菌中拯救斑马鱼胚胎。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号