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首页> 外文期刊>Journal of Oral Microbiology >The subgingival microbiomes in periodontitis and health of individuals with rheumatoid arthritis and at risk of developing rheumatoid arthritis
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The subgingival microbiomes in periodontitis and health of individuals with rheumatoid arthritis and at risk of developing rheumatoid arthritis

机译：类风湿关节炎及有发展成类风湿关节炎风险的个体的牙周炎和健康状况的龈下微生物群

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Serum anti-citrullinated protein antibodies (ACPAs), present in 70% of people with rheumatoid arthritis (RA), can be detected ≤10years before the onset of clinical disease. RA and periodontitis are epidemiologically associated and we have reported a high incidence of periodontitis in people who are ACPA+ and at risk of RA. Periodontal bacteria may contribute by multiple routes to the generation of RA-autoantibodies. This study aims to characterise the subgingival microbiomes from periodontitis and health in individuals with/without RA and at risk of RA.Forty-five ACPA+ no RA (RA-at-risk; RAR), 31 healthy controls (HC) and 30 ACPA+ RA patients (RA) underwent a periodontal examination. DNA from subgingival plaque from healthy and deep pocket sites were paired-end sequenced using the Illumina HiSeq3000 and data analysed using MG-RAST + DESeq.Metagenomes in RA samples had high proportions of Actinobacteria; RAR microbiomes contained higher proportions of Bacteroidetes than HC. The relative abundance o...
机译：70％的类风湿关节炎（RA）患者中存在血清抗瓜氨酸化蛋白抗体（ACPA），可在临床疾病发作前≤10年检测到。 RA和牙周炎在流行病学上相关，并且我们已经报告ACPA +且有RA风险的人牙周炎的发生率很高。牙周细菌可能通过多种途径促成RA自身抗体的产生。本研究旨在表征患有或不患有RA且有RA风险的个体的牙周炎和健康状况所致的龈下微生物群。四十五名ACPA +无RA（RA-高风险; RAR），31名健康对照（HC）和30名ACPA + RA患者（RA）接受牙周检查。使用Illumina HiSeq3000对来自健康和深袋部位的龈下斑块的DNA进行配对末端测序，并使用MG-RAST + DESeq对数据进行分析。 RAR微生物群比HC含有更高比例的拟杆菌。相对丰度

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