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首页> 外文期刊>Journal of Oral Microbiology >Prospective study of human herpesvirus 8 oral shedding, viremia, and serological status among human immunodeficiency virus seropositive and seronegative individuals in Sao Paulo, Brazil
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Prospective study of human herpesvirus 8 oral shedding, viremia, and serological status among human immunodeficiency virus seropositive and seronegative individuals in Sao Paulo, Brazil

机译：巴西圣保罗人类免疫缺陷病毒血清阳性和血清阴性人群中人类疱疹病毒8的口腔脱落，病毒血症和血清学状况的前瞻性研究

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Human herpesvirus 8 (HHV-8) is a gamma-herpesvirus and etiological agent of all forms of Kaposi sarcoma (KS). Saliva may play an important role in HHV-8 transmission in specific populations. Little is known about HHV-8 oral shedding pattern and the possible correlation with the HHV-8 serological profile and viremia. A prospective study was conducted of HHV-8 salivary excretion among human immunodeficiency virus HIV-seronegative (n?=?47) and -seropositive (n?=?44) homosexual men and HIV-seropositive women (n?=?32) over a 6-month period with monthly HHV-8 serologies (immunofluorescence assays to identify antibodies to latent and lytic HHV-8 viral proteins, and a whole-virus HHV-8 enzyme-linked immunosorbent assay [ELISA]), monthly HHV-8 DNA serum/plasma detection, and daily self-collected oral rinses for HHV-8-DNA detection using real-time polymerase chain reaction. HHV-8 seropositivity was 51.1%, 63.6%, and 37.5%, in the three studied groups. There was no case of HHV-8 DNA detection in serum/plasma...
机译：人疱疹病毒8（HHV-8）是伽马疱疹病毒和各种形式的卡波济肉瘤（KS）的病因。唾液可能在特定人群的HHV-8传播中起重要作用。关于HHV-8口腔脱落模式以及与HHV-8血清学特征和病毒血症的可能相关性知之甚少。在人类免疫缺陷病毒HIV血清阴性（n = 47）和-血清阳性（n = 44）的男性和HIV血清阳性女性（n = 32）中进行了HHV-8唾液排泄的前瞻性研究。为期6个月，每月进行HHV-8血清学检查（免疫荧光测定法，以鉴定针对HHV-8潜在和溶解性抗体的抗体，以及全病毒HHV-8酶联免疫吸附测定法[ELISA]），每月HHV-8 DNA血清/血浆检测，以及每天使用实时聚合酶链反应检测HHV-8-DNA的每日自行收集的口腔冲洗液。在三个研究组中，HHV-8血清阳性率为51.1％，63.6％和37.5％。血清/血浆中没有检测到HHV-8 DNA的病例...

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