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首页> 外文期刊>Journal of Nutritional Science >Improvement of glucose and lipid metabolism via mung bean protein consumption: clinical trials of GLUCODIA邃? isolated mung bean protein in the USA and Canada
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Improvement of glucose and lipid metabolism via mung bean protein consumption: clinical trials of GLUCODIA邃? isolated mung bean protein in the USA and Canada

机译：通过食用绿豆蛋白改善葡萄糖和脂质代谢：GLUCODIA®的临床试验美国和加拿大的分离的绿豆蛋白

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The aim of the present study was to confirm the effects of a commercially available mung bean protein isolate (GLUCODIA?) on glucose and lipid metabolism. The main component of GLUCODIA? is 8S globulin, which constitutes 80 % of the total protein. The overall structure of this protein closely resembles soyabean β-conglycinin, which accounts for 20 % of total soya protein (soya protein isolate; SPI). Many physiological beneficial effects of β-conglycinin have been reported. GLUCODIA? is expected to produce beneficial effects with fewer intakes than SPI. We conducted two independent double-blind, placebo-controlled clinical studies. In the first (preliminary dose decision trial) study, mung bean protein was shown to exert physiological beneficial effects when 3·0 g were ingested per d. In the second (main clinical trial) study, mung bean protein isolate did not lower plasma glucose levels, although the mean insulin level decreased with consumption of mung bean protein. The homeostatic model assessment of insulin resistance (HOMA-IR) values significantly decreased with mung bean protein. The mean TAG level significantly decreased with consumption of mung bean protein isolate. A significant increase in serum adiponectin levels and improvement in liver function enzymes were observed. These findings suggest that GLUCODIA? could be useful in the prevention of insulin resistance and visceral fat accumulation, which are known to trigger the metabolic syndrome, and in the prevention of liver function decline.
机译：本研究的目的是证实市售绿豆蛋白分离物（GLUCODIA？）对葡萄糖和脂质代谢的影响。 GLUCODIA的主要成分？是8S球蛋白，占总蛋白的80％。该蛋白质的整体结构与大豆β-伴大豆球蛋白非常相似，后者占大豆总蛋白（大豆分离蛋白; SPI）的20％。已经报道了β-伴大豆球蛋白的许多生理有益作用。糖尿？预计与SPI相比，其摄入量更少会产生有益的作用。我们进行了两项独立的双盲，安慰剂对照临床研究。在第一个（初步剂量决定试验）研究中，绿豆蛋白被证明每天摄入3·0 g可以发挥生理有益作用。在第二项（主要临床试验）研究中，尽管平均胰岛素水平随绿豆蛋白的消耗而降低，但绿豆蛋白分离物并未降低血浆葡萄糖水平。绿豆蛋白的胰岛素抵抗（HOMA-IR）值的稳态模型评估显着降低。随着食用绿豆蛋白分离物，平均TAG水平显着降低。观察到血清脂联素水平显着增加和肝功能酶改善。这些发现提示糖尿？可能有助于预防已知会触发代谢综合征的胰岛素抵抗和内脏脂肪蓄积，并有助于预防肝功能下降。

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