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首页> 外文期刊>Journal of Oral Microbiology >Defining saliva and tooth biofilm microbiota in adolescents in a low caries community and characterization by caries status
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Defining saliva and tooth biofilm microbiota in adolescents in a low caries community and characterization by caries status

机译：在低龋人群中定义唾液和牙齿生物膜微生物群，并通过龋齿状态进行表征

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The present study evaluated the microbiota of saliva and tooth biofilm by sequencing segments of the 16S rRNA gene using the common Illumina MiSeq (v3–v4) and the newer PacBio (v1–v8) sequencing platforms and searched for associations with caries in a low-caries population with regular dental care since early childhood. Saliva and tooth biofilm from adolescents and mock bacteria communities were analysed, including validity and reliability estimates. Caries was scored at baseline and 2 years later. The two sequencing platforms revealed similar microbiota patterns for saliva and tooth biofilm, respectively. Saliva microbiota discriminated caries-affected adolescents from caries-free adolescents with enumeration of five species in caries-affected participants and one species thereof predicting 2-year caries increment. Reliability was high and validity was acceptable if appropriate inclusion criteria were determined.
机译：本研究通过使用常见的Illumina MiSeq（v3-v4）和较新的PacBio（v1-v8）测序平台对16S rRNA基因的片段进行测序，评估了唾液和牙齿生物膜的微生物区系，并寻找了与龋齿的低关联性。从幼儿期开始定期进行牙齿保健的龋齿人群。分析了青少年和模拟细菌社区的唾液和牙齿生物膜，包括有效性和可靠性估计。在基线和2年后对龋齿评分。这两个测序平台分别揭示了唾液和牙齿生物膜的相似微生物群模式。唾液微生物群将龋齿影响的青少年与无龋齿的青少年区分开，列举了患龋的参与者中有5种，其中一种预测了2年龋齿的增加。如果确定了适当的纳入标准，则信度很高，信度是可以接受的。

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