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首页> 外文期刊>Journal of Oral Microbiology >Immunoglobulin G antibodies against Porphyromonas gingivalis or Aggregatibacter actinomycetemcomitans in cardiovascular disease and periodontitis
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Immunoglobulin G antibodies against Porphyromonas gingivalis or Aggregatibacter actinomycetemcomitans in cardiovascular disease and periodontitis

机译：抵抗牙龈卟啉单胞菌或放线杆菌的聚合酶G抗体在心血管疾病和牙周炎中的作用

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Objectives: The aim was to elucidate whether levels of circulating antibodies to Actinobacillus actinomycetemcomitans and Porphyromonas gingivalis correlate to loss of attachment, as a marker for periodontitis and cardiovascular disease (CVD).Design: Sera were collected from 576 participants of the Danish Health Examination Survey (DANHES). Immunoglobulin G antibodies against lipopolysaccharide (LPS) and protein antigens from the a, b and c serotypes of A. actinomycetemcomitans and P. gingivalis were quantified by titration in ELISA plates coated with a mixture of antigens prepared by disintegration of bacteria.Results: Levels of antibodies against P. gingivalis (OR?=?1.48) and A. actinomycetemcomitans (1.31) associated with periodontitis, as determined by univariable logistic regression analysis. These antibody levels also associated with CVD (1.17 and 1.37), respectively, However, after adjusting for other risk factors, including age, smoking, gender, alcohol consumption, overweight, and level o...
机译：目的：目的是阐明抗放线放线杆菌和牙龈卟啉单胞菌的循环抗体水平是否与附着丧失相关，作为牙周炎和心血管疾病（CVD）的标志。设计：血清来自丹麦健康检查调查的576名参与者（DANHES）。通过在涂有通过细菌分解制备的抗原混合物包被的ELISA板中进行滴定，对来自放线杆菌，齿肠线虫和牙龈卟啉单胞菌a，b和c血清型的脂多糖（LPS）和蛋白质抗原的免疫球蛋白G抗体进行定量。用单变量逻辑回归分析确定与牙周炎有关的牙龈卟啉单胞菌（ORα＝≥1.48）和放线放线杆菌（1.31）的抗体。这些抗体水平也分别与CVD相关（1.17和1.37），但是，在调整了其他风险因素后，包括年龄，吸烟，性别，饮酒，超重和o的水平。

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