• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Oral Microbiology >Porphyromonas gingivalis disturbs host–commensal homeostasis by changing complement function
【24h】

Porphyromonas gingivalis disturbs host–commensal homeostasis by changing complement function

机译：牙龈卟啉单胞菌通过改变补体功能干扰宿主-共生稳态

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Porphyromonas gingivalis is a Gram-negative anaerobic rod that has been proposed as an orchestrator of complement-dependent dysbiotic inflammation. This notion was suggested from its capacities to manipulate the complement–Toll-like receptor crosstalk in ways that promote dysbiosis and periodontal disease in animal models. Specifically, while at low colonization levels, P. gingivalis interferes with innate immunity and leads to changes in the counts and composition of the oral commensal microbiota. The resulting dysbiotic microbial community causes disruption of host–microbial homeostasis, leading to inflammatory bone loss. These findings suggested that P. gingivalis can be considered as a keystone pathogen. The concept of keystone pathogens is one where their effects have community-wide significance and are disproportionate of their abundance. The present review summarizes the relevant literature and discusses whether the results from the animal models can be extrapolated to man.
机译：牙龈卟啉单胞菌是革兰氏阴性厌氧棒，已被提议作为补体依赖性营养不良炎症的协调器。从以动物模型中促进营养不良和牙周疾病的方式操纵补体-Toll-样受体串扰的能力提出了这种想法。具体而言，在低定植水平下，牙龈卟啉单胞菌会干扰先天免疫​​，并导致口腔共生菌群的数量和组成发生变化。产生的不良生物微生物群落导致宿主-微生物体内稳态的破坏，导致炎症性骨丢失。这些发现表明，牙龈卟啉单胞菌可以被认为是关键病原体。关键病原体的概念是这样一种概念，其影响在整个社区具有重要意义，并且与其丰富程度不成比例。本综述总结了相关文献，并讨论了动物模型的结果是否可以推断给人类。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号