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首页> 外文期刊>Journal of Neurology Research >Repetitive Transcranial Magnetic Stimulation in Treatment of Levodopa-Induced Dyskinesia in Parkinson’s Disease
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Repetitive Transcranial Magnetic Stimulation in Treatment of Levodopa-Induced Dyskinesia in Parkinson’s Disease

机译：重复经颅磁刺激治疗左派多巴诱发的帕金森氏病运动障碍

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Background: Dyskinesia is one of the major complications of long-term dopaminergic treatment of Parkinson’s disease (PD), and deep brain stimulation may be the only satisfactory treatment for it. This study aims to search if there is any therapeutic effect of repetitive transcranial magnetic stimulation (rTMS) for levodopa-induced dyskinesia (LID) in PD patients. Methods: This study was conducted in Mansoura International Specialized Hospital in 43 complicated idiopathic PD patients. The patients with LID were divided into two groups matched in age, sex, duration and stage of the disease. Dyskinesia was detected by the Unified PD Rating Scale section IV. The patients of the study group (20 patients) received active rTMS, 5 Hz was applied bilaterally over the motor hand and leg areas of the cortex, in 20 trains, and each train is formed of 100 pulses, with 20-s inter-train interval. Ten sessions were administered once per day for 10 successive days for each patient. The patients of the control group (20 patients) received sham rTMS. Results: After rTMS, there was significant improvement in LID in the study group (P 0.001), while there was no improvement in the control one (P = 0.585). As regards to the LID clinical presentations, there was no significant difference between the two groups according to dyskinesia duration (P = 0.246), disability (P = 0.425) and early morning dystonia (P = 0.059), while there was significant improvement of painful dyskinesia in the study group (P = 0.046). Conclusions: The rTMS may have an additional therapeutic benefit for LID. Further studies may put the best rTMS parameters to establish more prominent and longer-lasting clinical effects.
机译：背景：运动障碍是帕金森病（PD）长期多巴胺能治疗的主要并发症之一，深部脑刺激可能是唯一令人满意的治疗方法。这项研究的目的是寻找重复性经颅磁刺激（rTMS）对PD患者左旋多巴诱发的运动障碍（LID）是否有任何治疗作用。方法：本研究在曼苏拉国际专科医院对43例特发性PD患者进行。 LID患者按年龄，性别，病程和疾病阶段分为两组。通过统一PD评分量表第IV部分检测到运动障碍。研究组的患者（20名患者）接受了主动rTMS，在20列火车中，在皮质的运动手和腿部区域双侧施加5 Hz频率，每列火车由100个脉冲组成，中间间隔20 s间隔。每位患者每天连续进行10天，每次10次。对照组的患者（20名患者）接受了假rTMS。结果：rTMS后，研究组的LID显着改善（P <0.001），而对照组的LID没有改善（P = 0.585）。关于LID临床表现，两组之间在运动障碍持续时间（P = 0.246），残疾（P = 0.425）和清晨肌张力障碍（P = 0.059）方面无显着差异，而疼痛的改善明显研究组运动障碍（P = 0.046）。结论：rTMS对LID可能具有其他治疗益处。进一步的研究可能将最佳的rTMS参数用于建立更突出和更持久的临床效果。

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