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首页> 外文期刊>Journal of orthopaedics and traumatology: official journal of the Italian Society of Orthopaedics and Traumatology >Knee chondral lesions treated with autologous chondrocyte transplantation in a tridimensional matrix: clinical evaluation at 1-year follow-up
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Knee chondral lesions treated with autologous chondrocyte transplantation in a tridimensional matrix: clinical evaluation at 1-year follow-up

机译：三维基质中自体软骨细胞移植治疗膝关节软骨病变：1年随访的临床评估

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class="Heading">Background class="Para">Despite the many studies on chondral injury repair, no outcomes have been evaluated with the Western Ontario and McMaster (WOMAC) Universities osteoarthritis index, the Knee Injury and Osteoarthritis Outcome Score (KOOS), and the Oxford Knee Score, all of which are specific for evaluating the presence of osteoarthritis. class="Heading">Materials and methods class="Para">We evaluated the clinical progress of patients following autologous chondrocyte implantation (ACI) performed by our Bone and Tissue Bank using a technique in which cells, instead of being introduced to the articular defect in a liquid form, are implanted into a tridimensional matrix of semisolid collagen (Condrograft?). A total of 22 patients underwent the procedure, 15 of whom were available for a 1-year follow-up that included clinical evaluation by WOMAC score before and after surgery and KOOS and the Oxford Knee Score after surgery. class="Heading">Results class="Para">The results were improved WOMAC score from 56.4 before surgery to 16.2 after surgery (P??0.002), average KOOS score of 83.6, and average Oxford Knee Score of 18.8. class="Heading">Conclusions class="Para">These results indicate that our tridimensional matrix technique effectively improved patients’ quality of life, at least in the short term, and delayed any subsequent procedure. Long-term assessment is necessary to determine the true value of this technique.
机译：class =“ Heading”>背景 class =“ Para”>尽管有关软骨损伤修复的研究很多，但西安大略和麦克马斯特（WOMAC）大学的骨关节炎指数，膝关节尚未评估任何结果损伤和骨关节炎结果评分（KOOS）以及牛津膝关节评分，所有这些都专门用于评估骨关节炎的存在。 class =“ Heading”>材料和方法 class = “ Para“>我们评估了由骨和组织库进行的自体软骨细胞植入（ACI）后患者的临床进展，该技术使用将细胞而不是以液体形式引入关节缺损的方法植入三维半固体胶原蛋白基质（Condrograft ？）。共有22例患者接受了该手术，其中15例可进行为期1年的随访，包括通过手术前后的WOMAC评分以及术后的KOOS和牛津膝关节评分进行临床评估。 类=“ Heading”>结果 class =“ Para”>结果将WOMAC评分从手术前的56.4提高到术后的16.2（ P ？<？0.002 ），平均KOOS得分为83.6，牛津膝盖平均得分为18.8。 class =“ Heading”>结论 class =“ Para”>这些结果表明，我们的三维矩阵技术有效至少在短期内改善了患者的生活质量，并延迟了任何后续手术。要确定该技术的真实价值，必须进行长期评估。

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