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首页> 外文期刊>Journal of Nutritional Science and Vitaminology >Dietary Supplementation with a Low Dose of (?)-Epigallocatechin-3-Gallate Reduces Pro-Inflammatory Responses in Peripheral Leukocytes of Non-Obese Type 2 Diabetic GK Rats
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Dietary Supplementation with a Low Dose of (?)-Epigallocatechin-3-Gallate Reduces Pro-Inflammatory Responses in Peripheral Leukocytes of Non-Obese Type 2 Diabetic GK Rats

机译：膳食补充低剂量的（？）-Epigallocatechin-3-Gallate可以降低非肥胖2型糖尿病GK大鼠外周血白细胞的促炎反应

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(?)-Epigallocatechin-3-gallate (EGCG), which is largely found in green tea, is known to eliminate reactive oxygen species and associated inflammatory responses in vitro and in cells. However, the in vivo mechanisms underlying the effects of EGCG on the amelioration of metabolic disorders are not fully understood. In this study, we examined whether dietary supplementation with EGCG reduces inflammatory responses in peripheral leukocytes of a non-obese type 2 diabetes animal model, Goto-Kakizaki (GK) rats. GK rats at 9 wk of age were fed a control high-fat diet (46 energy % from lard and corn oil) or a high-fat diet containing 0.1%, 0.2%, or 0.5% EGCG (w/w) for 25 wk. The oxidative stress markers 8-hydroxydeoxyguanosine (OHdG) and total malondialdehyde (MDA) were reduced by supplementation with EGCG at 0.1%, but not at 0.2% or more. Significant reductions in the mRNA levels of genes related to inflammatory responses (TNF-α, IFN-γ, IL-1β, IL-6, IL-18, MCP-1, CD11b, and S100a6), 8-OHdG, and total MDA were induced in peripheral leukocytes of GK rats by EGCG supplementation at 0.1%, but not at 0.2% or more, compared with rats fed the control diet. The present results suggest that supplementation with a low dose of EGCG reduces oxidative stress and the expressions of genes involved in inflammation in peripheral leukocytes of GK rats.
机译：（？）-Epigallocatechin-3-gallate（EGCG）大量存在于绿茶中，已知可以在体外和细胞中消除活性氧和相关的炎症反应。然而，尚未完全了解EGCG对改善代谢紊乱的影响的体内机制。在这项研究中，我们检查了饮食是否添加了EGCG可以降低非肥胖2型糖尿病动物模型五岛崎崎（GK）大鼠的外周白细胞的炎症反应。在9周龄的GK大鼠中饲喂25周的对照高脂饮食（猪油和玉米油的46％能量）或含有0.1％，0.2％或0.5％EGCG（w / w）的高脂饮食。氧化应激标记物8-羟基脱氧鸟苷（OHdG）和总丙二醛（MDA）通过添加0.1％而不是0.2％或更多的EGCG降低。与炎症反应相关的基因（TNF-α，IFN-γ，IL-1β，IL-6，IL-18，MCP-1，CD11b和S100a6），8-OHdG和总MDA的mRNA水平显着降低与饲喂对照饮食的大鼠相比，通过添加0.1％EGEG而不是0.2％或更高的EGCG可以在GK大鼠的外周血白细胞中诱导“红血球”生成。目前的结果表明，低剂量的EGCG补充可降低氧化应激和GK大鼠外周血白细胞中炎症相关基因的表达。

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