...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Osteoporosis >HIV and Bone Disease: A Perspective of the Role of microRNAs in Bone Biology upon HIV Infection
【24h】

HIV and Bone Disease: A Perspective of the Role of microRNAs in Bone Biology upon HIV Infection

机译：HIV和骨骼疾病：microRNA在感染HIV的骨骼生物学中的作用的观点

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Increased life expectancy and the need for long-term antiretroviral therapy have brought new challenges to the clinical management of HIV-infected individuals. The prevalence of osteoporosis and fractures is increased in HIV-infected patients; thus optimal strategies for risk management and treatment in this group of patients need to be defined. Prevention of bone loss is an important component of HIV care as the HIV population grows older. Understanding the mechanisms by which HIV infection affects bone biology leading to osteoporosis is crucial to delineate potential adjuvant treatments. This review focuses on HIV-induced osteoporosis within the context of microRNAs (miRNAs) by reviewing first basic concepts of bone biology as well as current knowledge of the role of miRNAs in bone development. Evidence that HIV-associated osteoporosis is in part independent of therapies employed to treat HIV (HAART) is supported by cross-sectional and longitudinal studies and is the focus of this review.
机译：预期寿命的延长和对长期抗逆转录病毒疗法的需求给艾滋病毒感染者的临床管理带来了新的挑战。 HIV感染患者的骨质疏松症和骨折患病率增加;因此，需要确定该组患者风险管理和治疗的最佳策略。随着艾滋病毒人口的增长，预防骨质流失是艾滋病毒护理的重要组成部分。了解HIV感染影响导致骨质疏松的骨骼生物学的机制对于描述潜在的辅助治疗至关重要。这篇综述通过回顾骨骼生物学的第一个基本概念以及关于miRNA在骨骼发育中作用的最新知识，着重讨论了在microRNA（miRNA）背景下HIV引起的骨质疏松症。横断面研究和纵向研究支持了与艾滋病毒相关的骨质疏松症部分独立于治疗艾滋病毒（HAART）的证据，这是本综述的重点。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号