• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of orthopaedics and traumatology: official journal of the Italian Society of Orthopaedics and Traumatology >Do bisphosphonates reduce early micromotion and Periprosthetic bone loss in total knee arthroplasty? A review of the evidence
【24h】

Do bisphosphonates reduce early micromotion and Periprosthetic bone loss in total knee arthroplasty? A review of the evidence

机译：双膦酸盐能减少全膝关节置换术中的早期微运动和假肢周围骨质流失吗？证据审查

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Early micromotion of implant components and periprosthetic bone loss in patients undergoing total knee arthroplasty are thought to contribute to late aseptic loosening. In the pursuit of longer implant survival, the administration of bisphosphonates may be advocated as a means to buffer implants against microinstability and periprosthetic bone loss. A bibliographic search identified one metaanalysis and two randomised controlled trials dealing with this topic. Current evidence supports the hypothesis that the inhibiting effects of bisphosphonates on bone resorption reduce implant micromotion and periprosthetic bone loss at the one-year follow-up. Tested bisphosphonates include clodronate, pamidronate and alendronate. However, a decline in periprosthetic BMD is observed at the three-year follow-up following a sixmonth course of bisphosphonate administration. Length of follow-up in available studies is currently too short to determine whether bisphosphonates increase the longevity of implants. Furthermore, the optimal dose, modality and length of bisphosphonate administration have yet to be determined.
机译：人们认为，在进行全膝关节置换术的患者中，植入物成分的早期微动和假体周围的骨质流失会导致晚期无菌性松动。为了追求更长的植入物生存期，可以建议使用双膦酸盐作为缓冲植入物以防止微不稳定和假体周围骨质流失的手段。书目搜索确定了一项针对该主题的荟萃分析和两项随机对照试验。当前的证据支持这样的假说，即在一年的随访中，双膦酸盐对骨吸收的抑制作用会降低植入物的微运动和假体周围的骨质流失。经测试的双膦酸盐包括氯膦酸盐，帕米膦酸盐和阿仑膦酸盐。然而，在双磷酸盐治疗六个月的疗程后的三年随访中，观察到假体周围骨密度降低。目前可用研究的随访时间太短，无法确定双膦酸盐是否会延长植入物的寿命。此外，双膦酸盐给药的最佳剂量，方式和时间尚未确定。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号