• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of orthopaedics and traumatology: official journal of the Italian Society of Orthopaedics and Traumatology >Time course of thrombosis and fibrinolysis during total hip surgery
【24h】

Time course of thrombosis and fibrinolysis during total hip surgery

机译：全髋关节手术期间血栓形成和纤维蛋白溶解的时程

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Venous thrombosis is common in elective hip surgery, and prophylactic treatment is used up to 12 hours before or after surgery. Recent clinical trials suggested that the timing of initiating prophylaxis significantly influenced the antithrombotic effectiveness. Furthermore, the timing of initiating antifibrinolytic treatment to reduce blood loss has been a question of debate. We studied the time course of coagulation and fibrinolysis at all phases during total hip arthroplasty. Specific markers of thrombosis (prothrombin fragment F1.2) and of fibrinolysis (plasminantiplasmin (PAP) and D-dimer) were examined in eight female and two male patients aged 16–62 years. There was a progressive increase in plasma concentrations of F1.2 during the operation. From the end of operation to 4 hours afterwards, there was no further increase in F1.2. Levels of D-dimer did not change until wound closure, when they began to increase up to 4 hours postoperatively, but there were no changes in PAP during the operation or during the 4-h postoperative period. Therefore, surgery for total hip arthroplasty activates thrombin generation during operation with fibrin degradation at a later stage. These observations harmonize with the notion that the interval between surgery and first administration of antithrombotic treatment is a critical variable.
机译：静脉血栓形成在选择性髋部手术中很常见，并且在手术前后最多12小时进行预防性治疗。最近的临床试验表明，开始预防的时机显着影响了抗血栓形成的有效性。此外，开始抗纤溶治疗以减少失血的时机已经成为争论的问题。我们研究了全髋关节置换术各个阶段的凝血和纤维蛋白溶解的时间过程。在8名16岁至62岁的男性和2名男性患者中检查了血栓形成（凝血酶原片段F1.2）和纤维蛋白溶解（纤溶酶原纤溶酶（PAP）和D-二聚体）的特异性标志物。术中血浆F1.2浓度逐渐增加。从运行结束到之后的4个小时，F1.2不再增加。 D-二聚体的水平直到伤口闭合后才发生变化，直到术后4小时才开始增加，但是在手术过程中或术后4小时内PAP没有变化。因此，全髋关节置换术在手术过程中会激活凝血酶生成，并在稍后阶段使纤维蛋白降解。这些观察结果与以下观念相一致：手术与首次使用抗栓治疗之间的间隔是一个关键变量。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号