• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of orthopaedics and traumatology: official journal of the Italian Society of Orthopaedics and Traumatology >The effects of transforming growth factor β1, insulin-like growth factor 1 and leptin on the proliferation of fetal chondrocytes
【24h】

The effects of transforming growth factor β1, insulin-like growth factor 1 and leptin on the proliferation of fetal chondrocytes

机译：转化生长因子β1，胰岛素样生长因子1和瘦素对胎儿软骨细胞增殖的影响

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

One method to exogenously enhance the repair of articular cartilage is the local application of growth factors. This method is based on the chondrogenic effects of some agents and their potential ability to enhance cell migration. Human fetal chondrocytes were isolated and cultured. Their proliferation under the influence of different agents was microscopically evaluated. Fetal calf serum at 5% and 10% concentrations induced microscopically visible cell proliferation. Transforming growth factor beta one (5 and 10 ng/ml), insulin-like growth factor 1 (5 and 10 nmol/l) and leptin (1 and 2 ng/ml) accelerated proliferation of the cells towards the increasing gradient of the agents. Fibroblast growth factor beta (5 and 10 ng/ml), bone morphogenic protein two (10 ng/ml) and laminin (1 mg/ml) did not affect cell proliferation. This study suggests that different agents can play a role in the proliferation of fetal chondrocytes.
机译：外源性增强关节软骨修复的一种方法是局部应用生长因子。该方法基于某些药物的软骨形成作用及其增强细胞迁移的潜在能力。分离并培养人胎儿软骨细胞。显微镜下评估了它们在不同药剂作用下的增殖。 5％和10％浓度的胎牛血清可引起显微镜下可见的细胞增殖。转化生长因子β1（5和10 ng / ml），胰岛素样生长因子1（5和10 nmol / l）和瘦素（1和2 ng / ml）促进细胞向着逐渐增加的药剂梯度扩散。成纤维细胞生长因子β（5和10 ng / ml），骨形态发生蛋白2（10 ng / ml）和层粘连蛋白（1 mg / ml）不会影响细胞增殖。这项研究表明，不同的药物可以在胎儿软骨细胞的增殖中发挥作用。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号