Background class='Para'>Blood transfusion is often required in total knee replacement; various methods of blood preservation have been studied. The best solution is to reduce the'/> Fibrin tissue adhesive reduces postoperative blood loss in total knee arthroplasty
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首页> 外文期刊>Journal of orthopaedics and traumatology: official journal of the Italian Society of Orthopaedics and Traumatology >Fibrin tissue adhesive reduces postoperative blood loss in total knee arthroplasty
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Fibrin tissue adhesive reduces postoperative blood loss in total knee arthroplasty

机译：纤维蛋白组织粘合剂可减少全膝关节置换术后的失血量

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class="Heading">Background class="Para">Blood transfusion is often required in total knee replacement; various methods of blood preservation have been studied. The best solution is to reduce the loss of blood during and after surgery. class="Heading">Materials and methods class="Para">We designed this study to evaluate the hemostatic efficacy and safety of fibrin tissue adhesive (Quixil) in patients receiving total knee arthroplasty [low contact stress (LCS, DePuy, Warsaw, IN, US) cementless total knee replacement (TKR)] with a prospective, randomized, standard treatment controlled study. Thirty-five patients were randomized to receive treatment with fibrin tissue adhesive (treatment group), and 35 were randomized to be managed with postoperative blood recovery and reinfusion (control group). Blood loss in suction drain, decrease in hemoglobin values, and transfusions were recorded. class="Heading">Results class="Para">A significant reduction in apparent total blood loss was detected in the treatment group compared with the control group. There was also a lower decrease in hemoglobin level, although this difference was not significant. When fibrin tissue adhesive was administered, the need for transfusions was lower. No major adverse events were recorded in our series. class="Heading">Conclusions class="Para">Fibrin tissue adhesive reduced blood loss in TKR and seemed to significantly reduce the need for blood transfusion. Fibrin tissue adhesive can be an appropriate solution to enhance hemostasis and vessel sealing at the operative site in TKR, in order to reduce blood loss after surgery and the risk of complications.
机译：class =“ Heading”>背景 class =“ Para”>全膝关节置换术通常需要输血;已经研究了多种血液保存方法。最好的解决方案是减少手术期间和手术后的失血。 class =“ Heading”>材料和方法 class =“ Para”>我们设计了此项研究以评估止血纤维蛋白组织粘合剂（Quixil）在接受全膝关节置换术[低接触应力（LCS，DePuy，华沙，印第安纳州，美国）的非骨水泥全膝关节置换术（TKR）]患者中的有效性和安全性，以及一项前瞻性，随机，标准治疗对照研究。 35例患者被随机分配接受纤维蛋白组织粘合剂治疗（治疗组），35例被随机分配接受术后血液恢复和再输注治疗（对照组）。记录了引流中的失血，血红蛋白值降低和输血。 class =“ Heading”>结果 class =“ Para”>，表观总失血量明显减少在治疗组中与对照组相比检测到的。血红蛋白水平的降低也较低，尽管这种差异并不明显。当施用纤维蛋白组织粘合剂时，输血的需求降低。在我们的系列中没有记录到重大的不良事件。 class =“ Heading”>结论 class =“ Para”>纤维蛋白组织胶粘剂减少了TKR的失血量，并且似乎大大减少了需求用于输血。纤维蛋白组织胶粘剂可能是增强TKR手术部位止血和血管封闭的合适解决方案，以减少手术后失血和并发症的风险。

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