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首页> 外文期刊>Journal of orthopaedics and traumatology: official journal of the Italian Society of Orthopaedics and Traumatology >Is there a link between the neutrophil-to-lymphocyte ratio and venous thromboembolic events after knee arthroplasty? A pilot study
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Is there a link between the neutrophil-to-lymphocyte ratio and venous thromboembolic events after knee arthroplasty? A pilot study

机译：膝关节置换术后中性粒细胞与淋巴细胞的比例与静脉血栓栓塞事件之间是否存在联系？初步研究

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This study aimed to identify (1) if the postoperative increase in the neutrophil-to-lymphocyte ratio (NLR) is different between contrasting knee arthroplasty procedures, and (2) if the NLR predicts venous thromboembolism (VTE) after total knee arthroplasty (TKA). To address the first objective, we retrospectively studied patients who underwent primary unilateral TKA (n = 111) or unicompartmental knee arthroplasty (UKA; n = 74) between 2009 and 2012. Patients who required a blood transfusion, underwent autologous blood salvage, experienced any postoperative complication (such as VTE), or were re-admitted 90 days were excluded from analysis. For the second objective, we retrospectively identified patients (cases, n = 10) who underwent primary unilateral TKA between 2010 and 2012 and developed postoperative VTE (deep venous thrombosis, pulmonary embolism, or both) during inpatient care (postoperative day 1 or day 2). Cases were matched to surgeon, gender, body mass index, age, and date of surgery controls (n = 20) who underwent primary unilateral TKA without developing VTE before patient discharge. The NLR was calculated from the neutrophil and lymphocyte counts extracted from pre- and postoperative (day 1 and day 2) blood chemistry records. On postoperative day 1, the NLR increase was exacerbated (p = 0.02) following TKA compared to UKA and predicted (p = 0.02) the occurrence of VTE in TKA patients prior to hospital discharge. We conclude that the NLR increase is greater following TKA compared to UKA and could serve as a matrix to predict or identify a patient susceptible of sustaining VTE after TKA. 3.
机译：这项研究旨在确定（1）对比的膝关节置换术之间中性粒细胞与淋巴细胞比例（NLR）的术后增加是否不同，以及（2）如果NLR预测全膝关节置换术（TKA）后静脉血栓栓塞（VTE） ）。为了实现第一个目标，我们回顾性研究了2009年至2012年间接受单侧TKA（n = 111）或单房膝关节置换术（UKA; n = 74）的患者。需要输血，接受自体血液抢救的患者，术后并发症（如VTE）或重新入院> 90天被排除在分析之外。为了第二个目标，我们回顾性鉴定了在2010年至2012年之间接受原发性单侧TKA并在住院治疗期间（术后第1天或第2天）发生术后VTE（深静脉血栓形成，肺栓塞或两者兼有）的患者（病例，n = 10）。 ）。将病例与外科医生，性别，体重指数，年龄和手术对照组的日期（n = 20）相匹配，这些患者在出院前接受了原发性单侧TKA而未发生VTE。根据从术前和术后（第1天和第2天）血液化学记录中提取的嗜中性粒细胞和淋巴细胞计数来计算NLR。术后第1天，与UKA相比，TKA后NLR加剧（p = 0.02），并预测（p = 0.02）出院前TKA患者发生VTE。我们得出的结论是，与UKA相比，TKA后NLR的增加更大，并且可以作为预测或识别TKA后易感维持VTE的患者的矩阵。 3。

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