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首页> 外文期刊>Journal of Pharmaceutics >Development of Budesonide Loaded Biopolymer Based Dry Powder Inhaler: Optimization,In VitroDeposition, and Cytotoxicity Study
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Development of Budesonide Loaded Biopolymer Based Dry Powder Inhaler: Optimization,In VitroDeposition, and Cytotoxicity Study

机译：布地奈德负载生物聚合物基干粉吸入器的开发：优化，体外沉积和细胞毒性研究

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The progress in the development of DPI technology has boosted the use of sensitive drug molecules for lung diseases. However, delivery of these molecules from conventional DPI to the active site still poses a challenge with respect to deposition efficiency in the lung. At same time, serious systemic side effects of drugs have become a cause for concern. The developed budesonide loaded biopolymer based controlled release DPI had shown maximumin vitrolung deposition with least toxicity. The subject of present study, lactose-free budesonide loaded biopolymer based DPI, further corroborates the great potential of antiasthmatic drugs. This technology is expected to revolutionize the approaches towards enhanced therapeutic delivery of prospective drugs.
机译：DPI技术的发展进步促进了敏感药物分子在肺部疾病中的使用。但是，将这些分子从常规DPI传递到活性部位仍然对肺部沉积效率构成挑战。同时，药物的严重全身性副作用已引起关注。已开发的以布地奈德负载的生物聚合物为基础的控释DPI表现出最大的体外肺沉积，且毒性最低。本研究的主题是无乳糖布地奈德生物聚合物基DPI，进一步证实了抗哮喘药的巨大潜力。预期该技术将彻底改变增强预期药物治疗性输送的方法。

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