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首页> 外文期刊>Journal of physiology and pharmacology: an official journal of the Polish Physiological Society >URINARY NEUTROPHIL GELATINASE-ASSOCIATED LIPOCALIN, KIDNEY INJURY MOLECULE-1, UROMODULIN, AND CYSTATIN C CONCENTRATIONS IN AN EXPERIMENTAL RAT MODEL OF ASCENDING ACUTE KIDNEY INJURY INDUCED BY PYELONEPHRITIS
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URINARY NEUTROPHIL GELATINASE-ASSOCIATED LIPOCALIN, KIDNEY INJURY MOLECULE-1, UROMODULIN, AND CYSTATIN C CONCENTRATIONS IN AN EXPERIMENTAL RAT MODEL OF ASCENDING ACUTE KIDNEY INJURY INDUCED BY PYELONEPHRITIS

机译：实验性肾炎急性肾炎大鼠模型中尿中性粒细胞明胶酶相关脂蛋白，肾损伤分子1，尿毒蛋白和胱抑素C浓度

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Recent evidence suggests that neutrophil gelatinase-associated lipocalin (NGAL), kidney injury molecule-1 (KIM-1), cystatin C (CysC), uromodulin (UMOD), and some interleukins (IL-6 and IL-18) can be considered as diagnostic markers of acute kidney injury (AKI). The aim of this study was to verify the applicability of four urinary (u) markers, namely uNGAL, uKIM-1, uCysC, and uUMOD, for the diagnosis of ascending AKI induced by bacterial pyelonephritis. The study included 30 female rats that were divided into three groups (n = 10 each) and were inoculated transurethrally with various doses of?Escherichia coli?to induce isolated pyelonephritis (group 1, 105?CFU/ml), pyelonephritis-induced AKI (group 2, 107?CFU/ml), or AKI and urosepsis (group 3, 109?CFU/ml). The inoculate contained a highly virulent?E. coli?strain isolated from a patient with pyelonephritis. Urine samples were obtained prior to the inoculation and 7, 14, and 21 days thereafter. The concentrations of all assessed proteins were determined in the urine samples by ELISA. All the study groups showed elevated concentrations of uNGAL and uCysC at all study time points. The concentrations of uKIM-1 in group 1 were the same as that at the baseline, whereas it was elevated in groups 2 and 3 at all study time points. The concentrations of uUMOD in groups 1 and 2 tended to decrease with the time from inoculation, whereas it rapidly increased in group 3 at 21 days postinfection. uKIM-1 seems to be the only marker of ascending AKI associated with urinary tract infection. Elevated concentrations of uNGAL, uCysC, and uUMOD were found in both AKI and isolated pyelonephritis. Thus, it can be concluded that none of these markers can be used as a single diagnostic marker of ascending AKI, as it may produce false-negative results, leading to incorrect diagnosis, lack of adequate treatment, and increased mortality risk.
机译：最近的证据表明，可以考虑中性粒细胞明胶酶相关的脂蛋白（NGAL），肾损伤分子1（KIM-1），胱抑素C（CysC），尿调节素（UMOD）和某些白介素（IL-6和IL-18）。作为急性肾损伤（AKI）的诊断标记。这项研究的目的是验证四种尿（u）标记，即uNGAL，uKIM-1，uCysC和uUMOD，用于诊断由细菌性肾盂肾炎引起的AKI升高的适用性。该研究包括30只雌性大鼠，将其分为三组（每组n = 10），并经尿道接种不同剂量的“大肠杆菌”以诱导分离的肾盂肾炎（第1组，105？CFU / ml），由肾盂肾炎引起的AKI（第2组为107？CFU / ml）或AKI和尿液（第3组为109？CFU / ml）。接种物中含有极强的毒力。从肾盂肾炎患者中分离出的大肠杆菌菌株。接种前以及接种后7、14和21天获取尿液样本。通过ELISA测定尿液样品中所有评估蛋白质的浓度。所有研究组在所有研究时间点均显示uNGAL和uCysC浓度升高。第1组中uKIM-1的浓度与基线时相同，而第2组和第3组中的uKIM-1在所有研究时间点均升高。第1组和第2组中uUMOD的浓度会随着接种时间的延长而降低，而第3组中的uUMOD浓度在感染后21天迅速增加。 uKIM-1似乎是与尿路感染相关的AKI升高的唯一标志。在AKI和孤立的肾盂肾炎中均发现uNGAL，uCysC和uUMOD的浓度升高。因此，可以得出结论，这些标记都不能用作AKI上升的单个诊断标记，因为它可能产生假阴性结果，从而导致错误的诊断，缺乏适当的治疗以及增加的死亡风险。

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