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首页> 外文期刊>Journal of Physics: Conference Series >Comparison of the goblet cells’ density and the quality of tears in treatment with sodium hyaluronate 0.1% benzalkonium chloride preservative-free eye drops for patients with glaucoma and dry-eye syndrome: A double-blind randomized clinical trial
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Comparison of the goblet cells’ density and the quality of tears in treatment with sodium hyaluronate 0.1% benzalkonium chloride preservative-free eye drops for patients with glaucoma and dry-eye syndrome: A double-blind randomized clinical trial

机译：透明质酸钠0.1％不含苯扎氯铵的防腐剂滴眼液治疗青光眼和干眼症患者杯状细胞密度和泪液质量的比较：一项双盲随机临床试验

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This study aims to compare the efficacy of benzalkonium chloride (BAK) on different goblet cells densities and to enhance the quality of tears in patients with glaucoma and dry-eye syndrome treated with preservative-free and preserved sodium hyaluronate (SH) 0.1% eye drops. In this double-blind, randomized clinical trial, we randomly assigned patients with glaucoma and dry-eye syndrome into two groups: group I, treated with SH 0.1% eye drops comprising BAK preservative (a positive comparator group); group II, treated with preservative-free SH 0.1% eye drops. We followed patients for 3 months after enrollment and assessed the quality of tears by examining symptoms and signs, including the Schirmer's test, tear film break-up time (TFBUT), Ocular Protection Index (OPI), and conjunctival impression cytology pre- and post-treatment. Any ocular discomfort was assessed by using the Ora Calibra Ocular. We enrolled 40 eyes from 20 patients with glaucoma and dry-eye syndrome. Each group comprised 20 eyes of 10 patients. We observed increased values of the mean TFBUT, OPI, and Schirmer's test pre- and post-treatment, with no significant difference between both groups. While the conjunctival impression cytology revealed similar results of goblet cells in both groups, we observed lower scale of the Ora Calibra Ocular. Both groups elicit a comparable improvement in the quality of tears as demonstrated by augmented results of the Schirmer's test, TFBUT, OPI, and Ora Calibra Ocular Score of patients with glaucoma and dry-eye syndrome.
机译：这项研究旨在比较苯扎氯铵（BAK）对不同杯状细胞密度的疗效，并提高接受无防腐剂和防腐剂透明质酸钠（SH）0.1％滴眼液治疗的青光眼和干眼症患者的眼泪质量。在这项双盲，随机临床试验中，我们将青光眼和干眼症患者随机分为两组：第一组，用含0.1％BAK防腐剂的SH 0.1％SH滴眼液治疗（阳性对照组）;第二组，用不含防腐剂的SH 0.1％眼药水治疗。我们在入组后对患者进行了3个月的随访，并通过检查症状和体征来评估眼泪的质量，包括Schirmer试验，泪膜破裂时间（TFBUT），眼保护指数（OPI）和结膜印前细胞学检查-治疗。通过使用Ora Calibra眼镜评估任何眼部不适。我们招募了20例青光眼和干眼症患者的40只眼。每组包括10名患者的20只眼睛。我们观察到治疗前和治疗后平均TFBUT，OPI和Schirmer's测试值均增加，两组之间无显着差异。虽然结膜印象细胞学检查显示两组的杯状细胞结果相似，但我们观察到口径较低的口杯。如青光眼和干眼症患者的Schirmer检验，TFBUT，OPI和Ora Calibra眼动评分的增强结果所表明的，两组在泪液质量方面均具有可比的改善。

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