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首页> 外文期刊>Cornea >Additive effect of preservative-free sodium hyaluronate 0.1% in treatment of dry eye syndrome with diquafosol 3% eye drops
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Additive effect of preservative-free sodium hyaluronate 0.1% in treatment of dry eye syndrome with diquafosol 3% eye drops

机译：0.1％不含防腐剂的透明质酸钠与3％的地夸磷索滴眼液治疗干眼症的相加作用

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Purpose: The aim of this study was to evaluate the treatment effect of diquafosol 3% with preservative-free sodium hyaluronate 0.1% eye drops in dry eye syndrome. Methods: In total, 150 patients with dry eye syndrome were divided randomly into 3 groups. Group 1 (50 patients) was treated 4 times daily with preserved sodium hyaluronate 0.1%, group 2 (50 patients) was treated 4 times daily with diquafosol 3%, and group 3 (50 patients) was treated 4 times daily with diquafosol 3% and preservative-free sodium hyaluronate 0.1% eye drops for 3 months. Ocular surface disease index (OSDI) score, tear film break-up time, Schirmer I test, corneal fluorescein staining, and impression cytology were evaluated. Results: There were significant improvements in the OSDI score, tear film break-up time, Schirmer I score, fluorescein and Rose Bengal staining, goblet cell density, and impression cytological findings in groups 2 and 3 compared with those for group 1 in patients with dry eye syndrome at 1, 2, and 3 months (P < 0.05). There were statistically significant improvements in the OSDI score (-8.48 ± 0.97, -5.69 ± 0.78; P = 0.02), fluorescein (-1.43 ± 0.21, -1.02 ± 0.18; P = 0.03), and Rose Bengal staining (-1.12 ± 0.26, -0.75 ± 0.12; P = 0.03), goblet cell density (89.65 ± 14.39, 70.36 ± 16.75; P = 0.03), and impression cytological findings (-0.53 ± 0.12, -0.34 ± 0.90; P = 0.01) in group 3 compared with those in group 2 at 3 months. Conclusions: Treatment with diquafosol 3% with preservative-free sodium hyaluronate 0.1% was more effective than diquafosol 3% monotherapy or treatment with preserved sodium hyaluronate 0.1% in dry eye syndrome. Preservative-free sodium hyaluronate 0.1% eye drops can increase the effect of diquafosol 3% in dry eye syndrome.
机译：目的：本研究的目的是评估0.1％无防腐剂的透明质酸钠滴眼液对3％地夸磷索在干眼综合征中的治疗效果。方法：将150例干眼症患者随机分为3组。第1组（50例患者）每天用0.1％的透明质酸钠保存4次，第2组（50例患者）每天用4％的地夸磷索治疗4次，第3组（50例患者）每天用4％的地夸磷索治疗4次和不含防腐剂的0.1％透明质酸钠眼药水3个月。评估了眼表疾病指数（OSDI）评分，泪膜破裂时间，Schirmer I测试，角膜荧光素染色和印模细胞学。结果：与第1组相比，在第2组和第3组中，OSDI评分，泪膜破裂时间，Schirmer I评分，荧光素和玫瑰红染色，杯状细胞密度和印模细胞学检查结果均较第1组有显着改善。在1、2和3个月时出现干眼症（P <0.05）。 OSDI评分（-8.48±0.97，-5.69±0.78; P = 0.02），荧光素（-1.43±0.21，-1.02±0.18; P = 0.03）和玫瑰孟加拉染色（-1.12±组0.26，-0.75±0.12; P = 0.03），杯状细胞密度（89.65±14.39，70.36±16.75; P = 0.03），印模细胞学检查结果（-0.53±0.12，-0.34±0.90; P = 0.01） 3个月时与第2组比较。结论：在干眼综合征中，用3％的地夸磷索和0.1％的不含防腐剂的透明质酸钠治疗比2％的地夸磷索单药或0.1％的透明质酸钠的治疗更有效。 0.1％不含防腐剂的透明质酸钠滴眼液可增加3％的地夸磷索在干眼症中的作用。

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