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首页> 外文期刊>Journal of pharmacological sciences. >Phenoxazine Derivatives Suppress the Infections Caused by Herpes Simplex Virus Type-1 and Herpes Simplex Virus Type-2 Intravaginally Inoculated Into Mice
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Phenoxazine Derivatives Suppress the Infections Caused by Herpes Simplex Virus Type-1 and Herpes Simplex Virus Type-2 Intravaginally Inoculated Into Mice

机译：苯恶嗪衍生物抑制小鼠阴道内接种单纯疱疹病毒1型和单纯疱疹病毒2型引起的感染。

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References(25) Cited-By(6) We examined the in vivo antiviral activities of 2-amino-4,4α-dihydro-4α-7-dimethyl-3H-phenoxazine-3-one (Phx-1), 3-amino-1,4α-dihydro-4α-8-dimethyl-2H-phenoxazine-2-one (Phx-2), and 2-aminophenoxazine-3-one (Phx-3) against herpes viruses. The virus yield three days after administration, changes in the 6-degree’s lesion scores, and the morbidity were assessed after herpes simplex virus type-1 (HSV-1) [acyclovir (ACV)-sensitive KOS strain or ACV-resistant A4-3 strain] or HSV-2 (ACV-sensitive UW 268 strain) was inoculated intravaginally to mice with administration of Phx-1, Phx-2, Phx-3, or ACV (0.2 mg per administration, 3 times daily) for 8 days starting from 1 day before virus inoculation to 7 days after infection. Phx-1, Phx-2, and Phx-3 extensively suppressed the virus yield of HSV-1. Only Phx-2 exerted moderate inhibitory effects against HSV-2 in mice. The lesion scores, as clinical signs manifested by infection of the KOS strain of HSV-1, were extensively suppressed by intravaginal application of Phx-1, Phx-2, or Phx-3. The lesion scores in HSV-2–infected mice indicated moderate suppression, when Phx-1, Phx-2, or Phx-3 was applied. Without treatment by one of the compounds, none of the HSV-1–infected mice died, but all the HSV-2–infected ones did. However, by the administration of Phx-1, Phx-2, or Phx-3 fairly improved the survival rates of the HSV-2–infected mice. Phx-2 showed dose-dependent anti-HSV-2 efficacy when administered at doses of 0.2 and 1 mg per administration. The present in vivo data suggest that the Phx-1, Phx-2, and Phx-3 are attractive candidates for agents to prevent both replication of HSV and aggravation of lesions caused by these viruses.
机译：参考文献（25）被引用者（6）我们研究了2-氨基-4,4α-二氢-4α-7-二甲基-3H-吩恶嗪-3-one（Phx-1），3-氨基的体内抗病毒活性-1,4α-二氢-4α-8-二甲基-2H-吩恶嗪-2-one（Phx-2）和2-氨基吩恶嗪-3-one（Phx-3）对抗疱疹病毒。用药三天后产生病毒，评估1度单纯疱疹病毒（HSV-1）[对阿昔洛韦（ACV）敏感的KOS株或对ACV耐药的A4-3）的6度病变评分和发病率毒株]或HSV-2（ACV敏感的UW 268株）阴道内接种给小鼠，分别接种Phx-1，Phx-2，Phx-3或ACV（每次给药0.2 mg，每天3次），开始8天从病毒接种前1天到感染后7天。 Phx-1，Phx-2和Phx-3广泛抑制了HSV-1的病毒产量。在小鼠中，只有Phx-2对HSV-2发挥了中度抑制作用。病变评分是由感染HSV-1的KOS菌株所表现出的临床症状，可通过阴道内应用Phx-1，Phx-2或Phx-3来广泛抑制。当使用Phx-1，Phx-2或Phx-3时，感染HSV-2的小鼠的病变评分表明有中等程度的抑制作用。如果不使用其中一种化合物进行治疗，则没有HSV-1感染的小鼠死亡，但是所有HSV-2感染的小鼠都死亡。但是，通过施用Phx-1，Phx-2或Phx-3可以大大提高HSV-2感染小鼠的存活率。当以每次给药0.2和1mg的剂量给药时，Phx-2显示出剂量依赖性的抗HSV-2功效。目前的体内数据表明，Phx-1，Phx-2和Phx-3是预防HSV复制和由这些病毒引起的病变加重的诱人药物。

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